Circulating plasma platinum more than 10 years after cisplatin treatment for testicular cancer

We have shown in patients cured from metastatic testicular cancer that up to 20 years after administration of cisplatincontaining chemotherapy, circulating platinum is still detectable in plasma. This finding may influence the development of longterm, treatment-related side-effects.

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Bibliographic Details
Published inThe Lancet (British edition) Vol. 355; no. 9209; pp. 1075 - 1076
Main Authors Gietema, JA, Meinardi, MT, Messerschmidt, J, Gelevert, T, Alt, F, Uges, DRA, Th Sleijfer, D
Format Journal Article
LanguageEnglish
Published London Elsevier Ltd 25.03.2000
Lancet
Elsevier Limited
Subjects
Adolescent
Adult
Antineoplastic agents
Biological and medical sciences
Cancer
Chemotherapy
Cisplatin - administration & dosage
Cisplatin - pharmacokinetics
Follow-Up Studies
Humans
Male
Medical sciences
Metabolic Clearance Rate - physiology
Pharmacology. Drug treatments
Plasma
Platinum
Platinum - pharmacokinetics
Side effects
Testicular Neoplasms - blood
Testicular Neoplasms - drug therapy
Antineoplastic agent
Human
Toxicity
Male
Metastasis
Malignant tumor
Retention
Testicle
Long term
Cisplatin
Alkylating agent
Chemotherapy
Treatment
Platinum
Complication
Evolution
Male genital diseases
Testicular diseases
Platinum II Complexes
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Summary:We have shown in patients cured from metastatic testicular cancer that up to 20 years after administration of cisplatincontaining chemotherapy, circulating platinum is still detectable in plasma. This finding may influence the development of longterm, treatment-related side-effects.
Bibliography:SourceType-Other Sources-1
content type line 63
ObjectType-Correspondence-1
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(00)02044-4