Recent Advances in Electrochemical and Optical Biosensors Designed for Detection of Interleukin 6

Interleukin 6 (IL-6), being a major component of homeostasis, immunomodulation, and hematopoiesis, manifests multiple pathological conditions when upregulated in response to viral, microbial, carcinogenic, or autoimmune stimuli. High fidelity immunosensors offer real-time monitoring of IL-6 and faci...

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Published inSensors (Basel, Switzerland) Vol. 20; no. 3; p. 646
Main Authors Khan, Munezza Ata, Mujahid, Mohammad
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 23.01.2020
MDPI
Subjects
Alzheimer's disease
Amino acids
Antibodies
Antigens
Binding sites
biosensor
Biosensors
Bone marrow
cancer detection
Cytokines
electrochemical sensor
Electrodes
Enzymes
Growth factors
Hepatitis
Hormones
Immunoassay
interleukin 6
Lymphoma
Medical research
Metabolism
Multiple myeloma
Nanoparticles
optical sensor
Proteins
Review
Rheumatoid arthritis
Tumor necrosis factor-TNF
interleukin 6
cancer detection
biosensor
electrochemical sensor
optical sensor
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Summary:Interleukin 6 (IL-6), being a major component of homeostasis, immunomodulation, and hematopoiesis, manifests multiple pathological conditions when upregulated in response to viral, microbial, carcinogenic, or autoimmune stimuli. High fidelity immunosensors offer real-time monitoring of IL-6 and facilitate early prognosis of life-threatening diseases. Different approaches to augment robustness and enhance overall performance of biosensors have been demonstrated over the past few years. Electrochemical- and fluorescence-based detection methods with integrated electronics have been subjects of intensive research due to their ability to offer a better signal-to-noise ratio, high specificity, ultra-sensitivity, and wide dynamic range. In this review, the pleiotropic role of IL-6 and its clinical significance is discussed in detail, followed by detection schemes devised so far for their quantitative analysis. A critical review on underlying signal amplification strategies and performance of electrochemical and optical biosensors is presented. In conclusion, we discuss the reliability and feasibility of the proposed detection technologies for commercial applications.
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These authors contributed equally to this work.
ISSN:1424-8220
1424-8220
DOI:10.3390/s20030646