Hormonal and Dietary Characteristics in Obese Human Subjects with and without Food Addiction

• Published in: Nutrients Vol. 7; no. 1; pp. 223 - 238
• Main Authors: Pedram, Pardis, Sun, Guang
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 31.12.2014; MDPI
• Subjects: adipokines; Adipokines - blood; Adult; adults; Appetite; Behavior, Addictive - blood; Biomarkers; Biomarkers - blood; Blood Glucose - metabolism; blood serum; Body Composition; Body Mass Index; Body Weight; calcium; Calories; Cholesterol, HDL - blood; Cholesterol, LDL - blood; Diet; digestive system; Dopamine; Drug addiction; eating disorders; Energy Intake; Exercise; Fasting; Feeding and Eating Disorders - blood; Female; Food; food intake; gamma-tocopherol; Gastrointestinal Hormones - blood; Hormones; Human subjects; Humans; Insulin - blood; Islet Amyloid Polypeptide - blood; Male; Metabolism; Micronutrients - administration & dosage; Middle Aged; minerals; Motor Activity; Neuropeptides; Neuropeptides - blood; Nutrients; Nutrition Assessment; Obesity; Obesity - blood; Overweight; physical activity; potassium; prolactin; Prolactin - blood; selenium; sodium; sugars; thyrotropin; trans fatty acids; Triglycerides - blood; tumor necrosis factor-alpha; Tumor Necrosis Factor-alpha - blood; vitamin D; Newfoundland & Labrador Canada; Canada
• ISSN: 2072-6643; 2072-6643
• DOI: 10.3390/nu7010223

The concept of food addiction (FA) is a potentially important contributing factor to the development of obesity in the general population; however, little is known about the hormonal and dietary differences between obesity with and without FA. Therefore, the aim of our study was to explore potential biomarkers, including various hormones and neuropeptides, which regulate appetite and metabolism, and dietary components that could potentially differentiate obesity with and without FA. Of the 737 adults recruited from the general Newfoundland population, 58 food-addicted and non-food-addicted overweight/obese individuals (FAO, NFO) matched for age, sex, BMI and physical activity were selected. A total of 34 neuropeptides, gut hormones, pituitary polypeptide hormones and adipokines were measured in fasting serum. We found that the FAO group had lower levels of TSH, TNF-α and amylin, but higher levels of prolactin, as compared to NFO group. The total calorie intake (per kg body weight), the dietary intake of fat (per g/kg body weight, per BMI and per percentage of trunk fat) and the percent calorie intake from fat and carbohydrates (g/kg) was higher in the FAO group compared to the NFO group. The FAO subjects consumed more sugar, minerals (including sodium, potassium, calcium and selenium), fat and its components (such as saturated, monounsaturated and trans fat), omega 3 and 6, vitamin D and gamma-tocopherol compared to the NFO group. To our knowledge, this is the first study indicating possible differences in hormonal levels and micro-nutrient intakes between obese individuals classified with and without food addiction. The findings provide insights into the mechanisms by which FA could contribute to obesity.