Oncolytic viruses-modulated immunogenic cell death, apoptosis and autophagy linking to virotherapy and cancer immune response

Recent reports have revealed that oncolytic viruses (OVs) play a significant role in cancer therapy. The infection of OVs such as oncolytic vaccinia virus (OVV), vesicular stomatitis virus (VSV), parvovirus, mammalian reovirus (MRV), human adenovirus, Newcastle disease virus (NDV), herpes simplex vi...

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Published inFrontiers in cellular and infection microbiology Vol. 13; p. 1142172
Main Authors Wu, Yi-Ying, Sun, Te-Kai, Chen, Ming-Shan, Munir, Muhammad, Liu, Hung-Jen
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 15.03.2023
Subjects
Animals
Apoptosis
Autophagy
Cellular and Infection Microbiology
Humans
immune system
Immunity
Immunogenic Cell Death
immunotherapy
Mammals
Neoplasms - therapy
Oncolytic Viruses
virotherapy
autophagy
immunogenic cell death
immunotherapy
immune system
apoptosis
oncolytic viruses
virotherapy
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Summary:Recent reports have revealed that oncolytic viruses (OVs) play a significant role in cancer therapy. The infection of OVs such as oncolytic vaccinia virus (OVV), vesicular stomatitis virus (VSV), parvovirus, mammalian reovirus (MRV), human adenovirus, Newcastle disease virus (NDV), herpes simplex virus (HSV), avian reovirus (ARV), Orf virus (ORFV), inactivated Sendai virus (ISV), enterovirus, and coxsackievirus offer unique opportunities in immunotherapy through diverse and dynamic pathways. This mini-review focuses on the mechanisms of OVs-mediated virotherapy and their effects on immunogenic cell death (ICD), apoptosis, autophagy and regulation of the immune system.
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Reviewed by: Zong Sheng Guo, University at Buffalo, United States
This article was submitted to Virus and Host, a section of the journal Frontiers in Cellular and Infection Microbiology
Edited by: Masmudur Mohammed Rahman, Arizona State University, United States
ISSN:2235-2988
2235-2988
DOI:10.3389/fcimb.2023.1142172