The evaluation of JAK inhibitors on effect and safety in alopecia areata: a systematic review and meta-analysis of 2018 patients

• Published in: Frontiers in immunology Vol. 14; p. 1195858
• Main Authors: Mao, Mei-Qi, Ding, Yu-Xin, Jing, Jing, Tang, Zhen-Wei, Miao, Yu-Jie, Yang, Xiao-Shuang, Chen, Yu-Hong, Chen, Sheng-Zhao, Wu, Xian-Jie, Lu, Zhong-Fa
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 02.06.2023
• Subjects: alopecia areata; Alopecia Areata - drug therapy; Autoimmune Diseases - drug therapy; Humans; immune-mediated diseases; Immunology; JAK inhibitors; JAK/STAT (janus kinase/signal transducer and activator of transcription); Janus Kinase Inhibitors - adverse effects; meta-analysis; Odds Ratio; meta-analysis; immune-mediated diseases; JAK/STAT (janus kinase/signal transducer and activator of transcription); alopecia areata; JAK inhibitors
• ISSN: 1664-3224; 1664-3224
• DOI: 10.3389/fimmu.2023.1195858

JAK inhibitors treat various autoimmune diseases, but an updated systematic review in treating alopecia areata is currently lacking. Evaluate the specific efficacy and safety of JAK inhibitors in alopecia areata by systematic review and meta-analysis. Eligible studies in PubMed, Embase, Web of Science, and Clinical Trials up to May 30, 2022, were searched. We enrolled in randomized controlled trials and observational studies of applying JAK inhibitors in alopecia areata. 6 randomized controlled trials with 1455 patients exhibited SALT (odd ratio [OR], 5.08; 95% confidence interval [CI], 3.49-7.38), SALT (OR, 7.40; 95% CI, 4.34-12.67) and change in SALT score (weighted mean difference [WSD], 5.55; 95% CI, 2.60-8.50) compared to the placebo. The proportion of 26 observational studies with 563 patients of SALT was 0.71(95% CI, 0.65-0.78), SALT was 0.54(95% CI 0.46-0.63), SALT was 0.33(95% CI, 0.24-0.42), and SALT score (WSD, -2.18; 95% CI, -3.12 to -1.23) compared with baseline. Any adverse effects occurred in 921 of 1508 patients; a total of 30 patients discontinued the trial owing to adverse reactions. Few randomized controlled trials met the inclusion criteria and insufficiency of eligible data. JAK inhibitors are effective in alopecia areata, although associated with an increased risk.