Zinc-modified titanium surface enhances osteoblast differentiation of dental pulp stem cells in vitro

Zinc is an essential trace element that plays an important role in differentiation of osteoblasts and bone modeling. This in vitro study aimed to evaluate the osteoblast differentiation of human dental pulp stem cells (DPSCs) on zinc-modified titanium (Zn-Ti) that releases zinc ions from its surface...

Full description

Saved in:
Bibliographic Details
Published inScientific reports Vol. 6; no. 1; p. 29462
Main Authors Yusa, Kazuyuki, Yamamoto, Osamu, Takano, Hiroshi, Fukuda, Masayuki, Iino, Mitsuyoshi
Format Journal Article
LanguageEnglish
Published England Nature Publishing Group 08.07.2016
Subjects
Alkaline Phosphatase - genetics
Alkaline Phosphatase - metabolism
Biomarkers - metabolism
Bone marrow
Cell Differentiation - drug effects
Cell Proliferation - drug effects
Cells, Cultured
Dental pulp
Dental Pulp - cytology
Dental Pulp - drug effects
Dental Pulp - metabolism
Dentistry
Extracellular Matrix - drug effects
Gene expression
Growth factors
Humans
In Vitro Techniques
Mineralization
Osteoblasts - cytology
Osteoblasts - drug effects
Phosphatase
Shear strength
Stem cells
Stem Cells - cytology
Stem Cells - drug effects
Stem Cells - metabolism
Surgery
Titanium
Titanium - chemistry
Transplants & implants
Up-Regulation
Zinc - chemistry
Zinc - pharmacology
Japan
Online AccessGet full text

Cover

Abstract Zinc is an essential trace element that plays an important role in differentiation of osteoblasts and bone modeling. This in vitro study aimed to evaluate the osteoblast differentiation of human dental pulp stem cells (DPSCs) on zinc-modified titanium (Zn-Ti) that releases zinc ions from its surface. Based on real-time PCR, alkaline phosphatase (ALP) activity and Western blot analysis data, we investigated osteoblast differentiation of DPSCs cultured on Zn-Ti and controls. DPSCs cultured on Zn-Ti exhibited significantly up-regulated gene expression levels of osteoblast-related genes of type I collagen (Col I), bone morphogenetic protein 2 (BMP2), ALP, runt-related transcription factor 2 (Runx2), osteopontin (OPN), and vascular endothelial growth factor A (VEGF A), as compared with controls. We also investigated extracellular matrix (ECM) mineralization by Alizarin Red S (ARS) staining and found that Zn-Ti significantly promoted ECM mineralization when compared with controls. These findings suggest that the combination of Zn-Ti and DPSCs provides a novel approach for bone regeneration therapy.
AbstractList Zinc is an essential trace element that plays an important role in differentiation of osteoblasts and bone modeling. This in vitro study aimed to evaluate the osteoblast differentiation of human dental pulp stem cells (DPSCs) on zinc-modified titanium (Zn-Ti) that releases zinc ions from its surface. Based on real-time PCR, alkaline phosphatase (ALP) activity and Western blot analysis data, we investigated osteoblast differentiation of DPSCs cultured on Zn-Ti and controls. DPSCs cultured on Zn-Ti exhibited significantly up-regulated gene expression levels of osteoblast-related genes of type I collagen (Col I), bone morphogenetic protein 2 (BMP2), ALP, runt-related transcription factor 2 (Runx2), osteopontin (OPN), and vascular endothelial growth factor A (VEGF A), as compared with controls. We also investigated extracellular matrix (ECM) mineralization by Alizarin Red S (ARS) staining and found that Zn-Ti significantly promoted ECM mineralization when compared with controls. These findings suggest that the combination of Zn-Ti and DPSCs provides a novel approach for bone regeneration therapy.
Abstract Zinc is an essential trace element that plays an important role in differentiation of osteoblasts and bone modeling. This in vitro study aimed to evaluate the osteoblast differentiation of human dental pulp stem cells (DPSCs) on zinc-modified titanium (Zn-Ti) that releases zinc ions from its surface. Based on real-time PCR, alkaline phosphatase (ALP) activity and Western blot analysis data, we investigated osteoblast differentiation of DPSCs cultured on Zn-Ti and controls. DPSCs cultured on Zn-Ti exhibited significantly up-regulated gene expression levels of osteoblast-related genes of type I collagen (Col I), bone morphogenetic protein 2 (BMP2), ALP, runt-related transcription factor 2 (Runx2), osteopontin (OPN) and vascular endothelial growth factor A (VEGF A), as compared with controls. We also investigated extracellular matrix (ECM) mineralization by Alizarin Red S (ARS) staining and found that Zn-Ti significantly promoted ECM mineralization when compared with controls. These findings suggest that the combination of Zn-Ti and DPSCs provides a novel approach for bone regeneration therapy.
Zinc is an essential trace element that plays an important role in differentiation of osteoblasts and bone modeling. This in vitro study aimed to evaluate the osteoblast differentiation of human dental pulp stem cells (DPSCs) on zinc-modified titanium (Zn-Ti) that releases zinc ions from its surface. Based on real-time PCR, alkaline phosphatase (ALP) activity and Western blot analysis data, we investigated osteoblast differentiation of DPSCs cultured on Zn-Ti and controls. DPSCs cultured on Zn-Ti exhibited significantly up-regulated gene expression levels of osteoblast-related genes of type I collagen (Col I), bone morphogenetic protein 2 (BMP2), ALP, runt-related transcription factor 2 (Runx2), osteopontin (OPN), and vascular endothelial growth factor A (VEGF A), as compared with controls. We also investigated extracellular matrix (ECM) mineralization by Alizarin Red S (ARS) staining and found that Zn-Ti significantly promoted ECM mineralization when compared with controls. These findings suggest that the combination of Zn-Ti and DPSCs provides a novel approach for bone regeneration therapy.
ArticleNumber 29462
Author Iino, Mitsuyoshi
Yamamoto, Osamu
Fukuda, Masayuki
Yusa, Kazuyuki
Takano, Hiroshi
Author_xml – sequence: 1
  givenname: Kazuyuki
  surname: Yusa
  fullname: Yusa, Kazuyuki
  organization: Department of Dentistry, Oral and Maxillofacial-Plastic and Reconstructive Surgery, School of Medicine, Yamagata University, Yamagata, Japan
– sequence: 2
  givenname: Osamu
  surname: Yamamoto
  fullname: Yamamoto, Osamu
  organization: Department of Bio-System Engineering, Graduate School of Science and Engineering, Yamagata University, Yonezawa, Japan
– sequence: 3
  givenname: Hiroshi
  surname: Takano
  fullname: Takano, Hiroshi
  organization: Division of Dentistry and Oral Surgery, Akita University School of Medicine, Akita, Japan
– sequence: 4
  givenname: Masayuki
  surname: Fukuda
  fullname: Fukuda, Masayuki
  organization: Division of Dentistry and Oral Surgery, Akita University School of Medicine, Akita, Japan
– sequence: 5
  givenname: Mitsuyoshi
  surname: Iino
  fullname: Iino, Mitsuyoshi
  organization: Department of Dentistry, Oral and Maxillofacial-Plastic and Reconstructive Surgery, School of Medicine, Yamagata University, Yamagata, Japan
BackLink https://www.ncbi.nlm.nih.gov/pubmed/27387130$$D View this record in MEDLINE/PubMed
BookMark eNpdkU9LHjEQxkNRqrUe-gUk4MUeVvN3N7kIIrYVBC_20kvIZmdrZDdZk-wL_fbmRftiO5eZYX48PMPzCe2FGAChL5ScU8LVRU6wMC1a9gEdMiJkwzhje-_mA3Sc8xOpJStH9Ud0wDquOsrJIYJfPrhmjoMfPQy4-GKDX2ec1zRaBxjCow0OMo65QOwnmwuu7AgJQvG2-BhwHPFQNzvhZZ0WXMEZO5imjH3AG19S_Iz2RztlOH7rR-jnt5uH6x_N3f332-uru8aJVpdGcsU1H0bX29YNrW6pdCBaK5nTRKmeSdEJkE7aFjrQBLq-V6yTYqRMDEzxI3T5qrus_QyDq66SncyS_GzTHxOtN_9egn80v-PGCM07IWkVOHsTSPF5hVzM7PP2FxsgrtlQRbgQnWRb9PQ_9CmuKdT3KkUZE1oxWamvr5RLMdeoxp0ZSsw2P7PLr7In793vyL9p8RcUMZl6
CitedBy_id crossref_primary_10_3390_biom13061006
crossref_primary_10_3390_ijms24054933
crossref_primary_10_1016_j_surfin_2022_102275
crossref_primary_10_1016_j_matdes_2021_109890
crossref_primary_10_1021_acsomega_4c01660
crossref_primary_10_1111_jre_12570
crossref_primary_10_1016_j_apsusc_2020_146107
crossref_primary_10_1021_acsami_0c15945
crossref_primary_10_1016_j_jallcom_2017_08_078
crossref_primary_10_1016_j_jmst_2022_09_060
crossref_primary_10_1016_j_procbio_2019_04_008
crossref_primary_10_3390_met7100402
crossref_primary_10_1016_j_jmbbm_2019_03_019
crossref_primary_10_1039_C7RA08263K
crossref_primary_10_1016_j_ceramint_2021_12_125
crossref_primary_10_2174_0929867326666190726123229
crossref_primary_10_1038_s41467_019_13479_6
crossref_primary_10_1016_j_jmst_2022_06_036
crossref_primary_10_1088_1748_605X_aa84e9
crossref_primary_10_1039_D0RA09395E
crossref_primary_10_3389_fbioe_2022_848769
crossref_primary_10_3390_ma13102211
crossref_primary_10_1016_j_jmst_2022_12_023
crossref_primary_10_1021_acsbiomaterials_1c01043
crossref_primary_10_3390_ma14041047
crossref_primary_10_1111_odi_14354
crossref_primary_10_1007_s10735_017_9719_2
crossref_primary_10_3390_ijms20020435
crossref_primary_10_1016_j_bioactmat_2021_01_011
crossref_primary_10_3390_bioengineering11010074
crossref_primary_10_1016_j_msec_2021_112594
crossref_primary_10_3390_bioengineering10121367
crossref_primary_10_1016_j_surfin_2023_103425
crossref_primary_10_1515_bglass_2019_0002
crossref_primary_10_1039_C8RA09112A
crossref_primary_10_1016_j_apsusc_2018_05_097
crossref_primary_10_1002_pat_4987
crossref_primary_10_1016_j_compstruct_2023_117236
crossref_primary_10_1002_adhm_202000681
crossref_primary_10_3390_jfb14030169
crossref_primary_10_1111_ijac_13493
crossref_primary_10_1002_cbin_10957
crossref_primary_10_3390_nano13101606
crossref_primary_10_3389_fphys_2017_00197
crossref_primary_10_1039_D3TB00119A
crossref_primary_10_1039_C8BM00021B
crossref_primary_10_1016_j_bioactmat_2020_08_025
crossref_primary_10_3390_life11050410
crossref_primary_10_4028_www_scientific_net_JBBBE_34_57
crossref_primary_10_1021_acsbiomaterials_0c00195
crossref_primary_10_1039_D0CS00103A
crossref_primary_10_3389_fmats_2021_739071
crossref_primary_10_3389_fmats_2021_646383
crossref_primary_10_1002_adem_202101510
crossref_primary_10_1002_adhm_202001369
Cites_doi 10.1111/j.1582-4934.2004.tb00320.x
10.1002/jbm.a.30040
10.1016/S0092-8674(00)80258-5
10.1002/(SICI)1097-4636(199802)39:2<331::AID-JBM22>3.0.CO;2-E
10.1073/pnas.78.12.7634
10.1007/978-1-60761-999-4_9
10.1210/endo.141.5.7458
10.1007/s10006-005-0602-z
10.4103/0972-124X.142469
10.1002/jbm.a.30518
10.1016/S0142-9612(98)00144-6
10.1016/j.jmbbm.2013.09.017
10.7150/ijbs.2929
10.1098/rsif.2008.0151
10.1007/s12015-015-9594-8
10.1016/j.cap.2004.10.006
10.1093/jn/106.7.905
10.1016/j.joms.2010.05.061
10.1023/A:1012905406548
10.1371/journal.pone.0140669
10.3390/ijms11041580
10.14712/18059694.2017.82
10.1359/jbmr.090602
10.5966/sctm.2015-0139
10.4162/nrp.2010.4.5.356
10.1038/336688a0
10.1007/s00441-009-0832-8
10.1016/j.msec.2014.01.022
10.1111/j.1708-8208.2011.00339.x
10.1016/j.tripleo.2008.12.018
10.1016/S0065-2776(08)00003-5
10.1101/gad.13.8.1025
10.1016/j.jtemb.2007.01.002
10.1016/j.bbrc.2011.07.082
10.1016/j.cell.2006.07.024
10.1038/sj.onc.1202064
10.1002/1097-4636(20010915)56:4<562::AID-JBM1128>3.0.CO;2-M
10.1371/journal.pone.0012743
10.1007/s11684-011-0164-4
10.1016/j.bone.2009.11.003
10.1016/j.cell.2007.11.019
10.1126/science.284.5411.143
10.1089/107632700300003323
10.1111/j.1708-8208.2010.00278.x
10.1002/stem.566
10.1093/jn/137.4.1101
10.1002/(SICI)1097-4636(19991205)47:3<396::AID-JBM15>3.0.CO;2-R
10.1002/jbm.a.10041
10.1007/s007740170058
10.1073/pnas.0937635100
10.1146/annurev.bioeng.8.061505.095721
10.1038/292154a0
10.1126/science.150.3698.893
10.1083/jcb.111.2.731
ContentType Journal Article
Copyright Copyright Nature Publishing Group Jul 2016
Copyright © 2016, Macmillan Publishers Limited 2016 Macmillan Publishers Limited
Copyright_xml – notice: Copyright Nature Publishing Group Jul 2016
– notice: Copyright © 2016, Macmillan Publishers Limited 2016 Macmillan Publishers Limited
DBID CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
3V.
7X7
7XB
88A
88E
88I
8FE
8FH
8FI
8FJ
8FK
ABUWG
AFKRA
AZQEC
BBNVY
BENPR
BHPHI
CCPQU
DWQXO
FYUFA
GHDGH
GNUQQ
HCIFZ
K9.
LK8
M0S
M1P
M2P
M7P
PIMPY
PQEST
PQQKQ
PQUKI
PRINS
Q9U
7X8
5PM
DOI 10.1038/srep29462
DatabaseName Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
ProQuest Central (Corporate)
Proquest Health and Medical Complete
ProQuest Central (purchase pre-March 2016)
Biology Database (Alumni Edition)
Medical Database (Alumni Edition)
Science Database (Alumni Edition)
ProQuest SciTech Collection
ProQuest Natural Science Collection
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest Central
ProQuest Central Essentials
Biological Science Collection
AUTh Library subscriptions: ProQuest Central
Natural Science Collection
ProQuest One Community College
ProQuest Central Korea
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
SciTech Premium Collection
ProQuest Health & Medical Complete (Alumni)
Biological Sciences
Health & Medical Collection (Alumni Edition)
PML(ProQuest Medical Library)
ProQuest Science Journals
Biological Science Database
Publicly Available Content Database
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
ProQuest Central Basic
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
Publicly Available Content Database
ProQuest Central Student
ProQuest Central Essentials
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
SciTech Premium Collection
ProQuest One Community College
ProQuest Natural Science Collection
ProQuest Central China
ProQuest Biology Journals (Alumni Edition)
ProQuest Central
Health Research Premium Collection
Health and Medicine Complete (Alumni Edition)
Natural Science Collection
ProQuest Central Korea
Biological Science Collection
ProQuest Medical Library (Alumni)
ProQuest Science Journals (Alumni Edition)
ProQuest Biological Science Collection
ProQuest Central Basic
ProQuest Science Journals
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
Biological Science Database
ProQuest SciTech Collection
ProQuest Hospital Collection (Alumni)
ProQuest Health & Medical Complete
ProQuest Medical Library
ProQuest One Academic UKI Edition
ProQuest One Academic
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList MEDLINE - Academic
CrossRef
MEDLINE

Publicly Available Content Database
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 3
  dbid: BENPR
  name: AUTh Library subscriptions: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
Dentistry
EISSN 2045-2322
EndPage 29462
ExternalDocumentID 4150685011
10_1038_srep29462
27387130
Genre Research Support, Non-U.S. Gov't
Journal Article
GeographicLocations Japan
GeographicLocations_xml – name: Japan
GroupedDBID 0R~
3V.
4.4
53G
5VS
7X7
88A
88E
88I
8FE
8FH
8FI
8FJ
AAFWJ
AAJSJ
AAKDD
ABDBF
ABUWG
ACGFS
ACSMW
ADBBV
ADRAZ
AENEX
AFKRA
AFPKN
AJTQC
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AOIJS
AZQEC
BAWUL
BBNVY
BCNDV
BENPR
BHPHI
BPHCQ
BVXVI
C6C
CCPQU
CGR
CUY
CVF
DIK
DWQXO
EBD
EBLON
EBS
ECM
EIF
EJD
ESX
FYUFA
GNUQQ
GROUPED_DOAJ
GX1
HCIFZ
HH5
HMCUK
HYE
KQ8
LK8
M0L
M1P
M2P
M48
M7P
M~E
NAO
NPM
OK1
PIMPY
PQQKQ
PROAC
PSQYO
RNT
RNTTT
RPM
SNYQT
UKHRP
AAYXX
CITATION
7XB
8FK
K9.
PQEST
PQUKI
PRINS
Q9U
7X8
AFGXO
5PM
ID FETCH-LOGICAL-c469t-538393dfcba6cd69615ce46a52c9088b25474e5c5a6e7e90e7bb82754f124d283
IEDL.DBID RPM
ISSN 2045-2322
IngestDate Tue Sep 17 21:27:13 EDT 2024
Fri Aug 16 09:15:59 EDT 2024
Fri Sep 13 08:37:15 EDT 2024
Fri Aug 23 02:54:34 EDT 2024
Sat Sep 28 08:50:01 EDT 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Language English
License This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c469t-538393dfcba6cd69615ce46a52c9088b25474e5c5a6e7e90e7bb82754f124d283
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
OpenAccessLink https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937451/
PMID 27387130
PQID 1812249825
PQPubID 2041939
PageCount 1
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_4937451
proquest_miscellaneous_1803447521
proquest_journals_1812249825
crossref_primary_10_1038_srep29462
pubmed_primary_27387130
PublicationCentury 2000
PublicationDate 2016-07-08
PublicationDateYYYYMMDD 2016-07-08
PublicationDate_xml – month: 07
  year: 2016
  text: 2016-07-08
  day: 08
PublicationDecade 2010
PublicationPlace England
PublicationPlace_xml – name: England
– name: London
PublicationTitle Scientific reports
PublicationTitleAlternate Sci Rep
PublicationYear 2016
Publisher Nature Publishing Group
Publisher_xml – name: Nature Publishing Group
References 18254273 - Acta Medica (Hradec Kralove). 2007;50(3):195-201
8752560 - Int J Oral Maxillofac Implants. 1996 May-Jun;11(3):387-94
11831463 - Biometals. 2001 Sep-Dec;14(3-4):331-41
20671800 - J Stem Cells. 2007;2(3):139-147
9182763 - Cell. 1997 May 30;89(5):755-64
19201629 - Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009 Apr;107(4):e1-8
14624496 - J Biomed Mater Res A. 2003 Dec 15;67(4):1115-22
20480036 - Int J Mol Sci. 2010 Apr 12;11(4):1580-678
15127402 - J Biomed Mater Res A. 2004 Jun 1;69(3):552-60
12716973 - Proc Natl Acad Sci U S A. 2003 May 13;100(10):5807-12
26586776 - Stem Cells Transl Med. 2016 Jan;5(1):95-105
16904174 - Cell. 2006 Aug 25;126(4):663-76
16834564 - Annu Rev Biomed Eng. 2006;8:455-98
5319761 - Science. 1965 Nov 12;150(3698):893-9
17499147 - J Trace Elem Med Biol. 2007;21(2):84-91
11156471 - J Bone Miner Metab. 2001;19(1):38-44
10803575 - Endocrinology. 2000 May;141(5):1667-74
3143917 - Nature. 1988 Dec 15;336(6200):688-90
10215629 - Genes Dev. 1999 Apr 15;13(8):1025-36
26529234 - PLoS One. 2015 Nov 03;10(11):e0140669
11224927 - Tissue Eng. 2001 Feb;7(1):89-99
17374687 - J Nutr. 2007 Apr;137(4):1101-5
19649655 - Cell Tissue Res. 2010 Jan;339(1):189-95
9457565 - J Biomed Mater Res. 1998 Feb;39(2):331-40
6950406 - Proc Natl Acad Sci U S A. 1981 Dec;78(12):7634-8
18667387 - J R Soc Interface. 2008 Oct 6;5(27):1137-58
11400134 - J Biomed Mater Res. 2001 Sep 15;56(4):562-70
26022504 - Stem Cell Rev. 2015 Aug;11(4):645-51
20856871 - PLoS One. 2010 Sep 14;5(9):e12743
1696268 - J Cell Biol. 1990 Aug;111(2):731-41
22198748 - Front Med. 2011 Dec;5(4):372-8
19558314 - J Bone Miner Res. 2009 Aug;24(8):1347-53
7242681 - Nature. 1981 Jul 9;292(5819):154-6
21103080 - Nutr Res Pract. 2010 Oct;4(5):356-61
18035408 - Cell. 2007 Nov 30;131(5):861-72
24582253 - Mater Sci Eng C Mater Biol Appl. 2014 Apr 1;37:305-13
20455903 - Clin Implant Dent Relat Res. 2010 May;12 Suppl 1:e114-25
21732479 - Stem Cells. 2011 Feb;29(2):206-16
58980 - J Nutr. 1976 Jul;106(7):905-12
24184863 - J Mech Behav Biomed Mater. 2014 Jan;29:393-402
18501770 - Adv Immunol. 2008;97:149-76
25425833 - J Indian Soc Periodontol. 2014 Sep;18(5):661-5
9884063 - Biomaterials. 1998 Dec;19(23):2219-32
22298955 - Int J Biol Sci. 2012;8(2):272-88
10487892 - J Biomed Mater Res. 1999 Dec 5;47(3):396-403
10102814 - Science. 1999 Apr 2;284(5411):143-7
11073979 - Mol Cell Biol. 2000 Dec;20(23):8783-92
21682843 - Clin Implant Dent Relat Res. 2013 Apr;15(2):166-75
15491506 - J Cell Mol Med. 2004 Jul-Sep;8(3):301-16
26747612 - J Bone Miner Metab. 2017 Jan;35(1):21-30
9794229 - Oncogene. 1998 Sep 24;17(12):1517-25
21431514 - Methods Mol Biol. 2011;698:107-21
21820411 - Biochem Biophys Res Commun. 2011 Aug 26;412(2):273-8
19913120 - Bone. 2010 Mar;46(3):732-41
20971544 - J Oral Maxillofac Surg. 2011 Jan;69(1):48-53
15711990 - Mund Kiefer Gesichtschir. 2005 Mar;9(2):63-5
16270344 - J Biomed Mater Res A. 2006 Feb;76(2):323-34
M Otsuka (BFsrep29462_CR16) 2004; 69
MF Pittenger (BFsrep29462_CR35) 1999; 284
M Sato (BFsrep29462_CR50) 1998; 17
MR Urist (BFsrep29462_CR48) 1965; 150
MJ Evans (BFsrep29462_CR23) 1981; 292
MO Klein (BFsrep29462_CR7) 2013; 15
D Beyersmann (BFsrep29462_CR11) 2001; 14
KM Hambidge (BFsrep29462_CR20) 2007; 137
W Tong (BFsrep29462_CR30) 2007; 2
Y Oshida (BFsrep29462_CR2) 2010; 11
K Yusa (BFsrep29462_CR42) 2011; 412
E Schipani (BFsrep29462_CR54) 2009; 24
S Gronthos (BFsrep29462_CR39) 2011; 698
S Wang (BFsrep29462_CR36) 2011; 5
U Frohberg (BFsrep29462_CR40) 2005; 9
BFsrep29462_CR34
K Narita (BFsrep29462_CR3) 2014; 29
AT von (BFsrep29462_CR4) 1996; 11
J Suchánek (BFsrep29462_CR58) 2007; 50
X Lou (BFsrep29462_CR32) 2015; 11
C Liu (BFsrep29462_CR9) 2015; 10
A Yamamoto (BFsrep29462_CR45) 1998; 39
ST Becker (BFsrep29462_CR41) 2011; 69
S Fujibayashi (BFsrep29462_CR10) 2001; 56
M Ikeuchi (BFsrep29462_CR15) 2003; 67
A Ito (BFsrep29462_CR17) 2005; 5
K Takahashi (BFsrep29462_CR26) 2006; 126
M Iino (BFsrep29462_CR5) 2009; 107
K Takahashi (BFsrep29462_CR27) 2007; 131
AG Smith (BFsrep29462_CR25) 1988; 336
LD Buttery (BFsrep29462_CR29) 2001; 7
RS Pekarek (BFsrep29462_CR13) 1976; 106
J Ji (BFsrep29462_CR33) 2016; 5
P Ducy (BFsrep29462_CR51) 1999; 13
J Lincks (BFsrep29462_CR43) 1998; 19
K Alvarez (BFsrep29462_CR22) 2010; 12
T Hirano (BFsrep29462_CR12) 2008; 97
S Deshpande (BFsrep29462_CR6) 2014; 18
MM Deckers (BFsrep29462_CR53) 2000; 141
HJ Seo (BFsrep29462_CR19) 2010; 4
G Chen (BFsrep29462_CR57) 2012; 8
H Egusa (BFsrep29462_CR28) 2010; 5
T Komori (BFsrep29462_CR49) 1997; 89
F Rupp (BFsrep29462_CR44) 2006; 76
G Bilousova (BFsrep29462_CR31) 2011; 29
T Komori (BFsrep29462_CR52) 2010; 339
A Yamamoto (BFsrep29462_CR46) 1999; 47
GR Martin (BFsrep29462_CR24) 1981; 78
WC Chen (BFsrep29462_CR8) 2014; 37
ZJ Ma (BFsrep29462_CR14) 2001; 19
M Navarro (BFsrep29462_CR1) 2008; 5
AG Robling (BFsrep29462_CR47) 2006; 8
KS Lee (BFsrep29462_CR56) 2000; 20
IS Kwun (BFsrep29462_CR21) 2010; 46
M Miura (BFsrep29462_CR38) 2003; 100
T Wang (BFsrep29462_CR18) 2007; 21
EY Yang (BFsrep29462_CR55) 1990; 111
D Baksh (BFsrep29462_CR37) 2004; 8
References_xml – volume: 8
  start-page: 301
  year: 2004
  ident: BFsrep29462_CR37
  publication-title: J Cell Mol Med.
  doi: 10.1111/j.1582-4934.2004.tb00320.x
  contributor:
    fullname: D Baksh
– volume: 69
  start-page: 552
  year: 2004
  ident: BFsrep29462_CR16
  publication-title: J Biomed Mater Res A.
  doi: 10.1002/jbm.a.30040
  contributor:
    fullname: M Otsuka
– volume: 89
  start-page: 755
  year: 1997
  ident: BFsrep29462_CR49
  publication-title: Cell.
  doi: 10.1016/S0092-8674(00)80258-5
  contributor:
    fullname: T Komori
– volume: 39
  start-page: 331
  year: 1998
  ident: BFsrep29462_CR45
  publication-title: J Biomed Mater Res.
  doi: 10.1002/(SICI)1097-4636(199802)39:2<331::AID-JBM22>3.0.CO;2-E
  contributor:
    fullname: A Yamamoto
– volume: 2
  start-page: 139
  year: 2007
  ident: BFsrep29462_CR30
  publication-title: J Stem Cells
  contributor:
    fullname: W Tong
– volume: 20
  start-page: 8783
  year: 2000
  ident: BFsrep29462_CR56
  publication-title: Cell Biol.
  contributor:
    fullname: KS Lee
– volume: 78
  start-page: 7634
  year: 1981
  ident: BFsrep29462_CR24
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.78.12.7634
  contributor:
    fullname: GR Martin
– volume: 698
  start-page: 107
  year: 2011
  ident: BFsrep29462_CR39
  publication-title: Methods Mol Biol.
  doi: 10.1007/978-1-60761-999-4_9
  contributor:
    fullname: S Gronthos
– volume: 141
  start-page: 1667
  year: 2000
  ident: BFsrep29462_CR53
  publication-title: Endocrinology.
  doi: 10.1210/endo.141.5.7458
  contributor:
    fullname: MM Deckers
– volume: 9
  start-page: 63
  year: 2005
  ident: BFsrep29462_CR40
  publication-title: Mund Kiefer Gesichtschir.
  doi: 10.1007/s10006-005-0602-z
  contributor:
    fullname: U Frohberg
– volume: 18
  start-page: 661
  year: 2014
  ident: BFsrep29462_CR6
  publication-title: J Indian Soc Periodontol.
  doi: 10.4103/0972-124X.142469
  contributor:
    fullname: S Deshpande
– volume: 76
  start-page: 323
  year: 2006
  ident: BFsrep29462_CR44
  publication-title: J Biomed Mater Res A.
  doi: 10.1002/jbm.a.30518
  contributor:
    fullname: F Rupp
– volume: 19
  start-page: 2219
  year: 1998
  ident: BFsrep29462_CR43
  publication-title: Biomaterials.
  doi: 10.1016/S0142-9612(98)00144-6
  contributor:
    fullname: J Lincks
– volume: 29
  start-page: 393
  year: 2014
  ident: BFsrep29462_CR3
  publication-title: J Mech Behav Biomed Mater.
  doi: 10.1016/j.jmbbm.2013.09.017
  contributor:
    fullname: K Narita
– volume: 8
  start-page: 272
  year: 2012
  ident: BFsrep29462_CR57
  publication-title: Int. J. Biol. Sci.
  doi: 10.7150/ijbs.2929
  contributor:
    fullname: G Chen
– volume: 5
  start-page: 1137
  year: 2008
  ident: BFsrep29462_CR1
  publication-title: J R Soc Interface
  doi: 10.1098/rsif.2008.0151
  contributor:
    fullname: M Navarro
– volume: 11
  start-page: 645
  year: 2015
  ident: BFsrep29462_CR32
  publication-title: Stem Cell Rev.
  doi: 10.1007/s12015-015-9594-8
  contributor:
    fullname: X Lou
– volume: 5
  start-page: 402
  year: 2005
  ident: BFsrep29462_CR17
  publication-title: Current Applied Physics.
  doi: 10.1016/j.cap.2004.10.006
  contributor:
    fullname: A Ito
– volume: 106
  start-page: 905
  year: 1976
  ident: BFsrep29462_CR13
  publication-title: J Nutr.
  doi: 10.1093/jn/106.7.905
  contributor:
    fullname: RS Pekarek
– volume: 69
  start-page: 48
  year: 2011
  ident: BFsrep29462_CR41
  publication-title: J Oral Maxillofac Surg.
  doi: 10.1016/j.joms.2010.05.061
  contributor:
    fullname: ST Becker
– volume: 14
  start-page: 331
  year: 2001
  ident: BFsrep29462_CR11
  publication-title: Biometals.
  doi: 10.1023/A:1012905406548
  contributor:
    fullname: D Beyersmann
– volume: 11
  start-page: 387
  year: 1996
  ident: BFsrep29462_CR4
  publication-title: Int J Oral Maxillofac Implants.
  contributor:
    fullname: AT von
– volume: 10
  start-page: e0140669
  year: 2015
  ident: BFsrep29462_CR9
  publication-title: PLoS One.
  doi: 10.1371/journal.pone.0140669
  contributor:
    fullname: C Liu
– volume: 11
  start-page: 1580
  year: 2010
  ident: BFsrep29462_CR2
  publication-title: Int J Mol Sci.
  doi: 10.3390/ijms11041580
  contributor:
    fullname: Y Oshida
– volume: 50
  start-page: 195
  year: 2007
  ident: BFsrep29462_CR58
  publication-title: Act Medica (Hradec Kralove)
  doi: 10.14712/18059694.2017.82
  contributor:
    fullname: J Suchánek
– volume: 24
  start-page: 1347
  year: 2009
  ident: BFsrep29462_CR54
  publication-title: J Bone Miner Res.
  doi: 10.1359/jbmr.090602
  contributor:
    fullname: E Schipani
– volume: 5
  start-page: 95
  year: 2016
  ident: BFsrep29462_CR33
  publication-title: Stem Cells Transl Med.
  doi: 10.5966/sctm.2015-0139
  contributor:
    fullname: J Ji
– volume: 4
  start-page: 356
  year: 2010
  ident: BFsrep29462_CR19
  publication-title: Nutr Res Pract.
  doi: 10.4162/nrp.2010.4.5.356
  contributor:
    fullname: HJ Seo
– volume: 336
  start-page: 688
  year: 1988
  ident: BFsrep29462_CR25
  publication-title: Nature
  doi: 10.1038/336688a0
  contributor:
    fullname: AG Smith
– volume: 339
  start-page: 189
  year: 2010
  ident: BFsrep29462_CR52
  publication-title: Cell Tissue Res.
  doi: 10.1007/s00441-009-0832-8
  contributor:
    fullname: T Komori
– volume: 37
  start-page: 305
  year: 2014
  ident: BFsrep29462_CR8
  publication-title: Mater Sci Eng C Mater Biol Appl.
  doi: 10.1016/j.msec.2014.01.022
  contributor:
    fullname: WC Chen
– volume: 15
  start-page: 166
  year: 2013
  ident: BFsrep29462_CR7
  publication-title: Clin Implant Dent Relat Res.
  doi: 10.1111/j.1708-8208.2011.00339.x
  contributor:
    fullname: MO Klein
– volume: 107
  start-page: e1
  year: 2009
  ident: BFsrep29462_CR5
  publication-title: Oral Surg Oral Med Oral Pathol Oral Radiol Endod.
  doi: 10.1016/j.tripleo.2008.12.018
  contributor:
    fullname: M Iino
– volume: 97
  start-page: 149
  year: 2008
  ident: BFsrep29462_CR12
  publication-title: Adv Immunol.
  doi: 10.1016/S0065-2776(08)00003-5
  contributor:
    fullname: T Hirano
– volume: 13
  start-page: 1025
  year: 1999
  ident: BFsrep29462_CR51
  publication-title: Genes Dev.
  doi: 10.1101/gad.13.8.1025
  contributor:
    fullname: P Ducy
– volume: 21
  start-page: 84
  year: 2007
  ident: BFsrep29462_CR18
  publication-title: J Trace Elem Med Biol.
  doi: 10.1016/j.jtemb.2007.01.002
  contributor:
    fullname: T Wang
– ident: BFsrep29462_CR34
– volume: 412
  start-page: 273
  year: 2011
  ident: BFsrep29462_CR42
  publication-title: Biochem Biophys Res Commun.
  doi: 10.1016/j.bbrc.2011.07.082
  contributor:
    fullname: K Yusa
– volume: 126
  start-page: 663
  year: 2006
  ident: BFsrep29462_CR26
  publication-title: Cell
  doi: 10.1016/j.cell.2006.07.024
  contributor:
    fullname: K Takahashi
– volume: 17
  start-page: 1517
  year: 1998
  ident: BFsrep29462_CR50
  publication-title: Oncogene.
  doi: 10.1038/sj.onc.1202064
  contributor:
    fullname: M Sato
– volume: 56
  start-page: 562
  year: 2001
  ident: BFsrep29462_CR10
  publication-title: J Biomed Mater Res.
  doi: 10.1002/1097-4636(20010915)56:4<562::AID-JBM1128>3.0.CO;2-M
  contributor:
    fullname: S Fujibayashi
– volume: 5
  start-page: e12743
  year: 2010
  ident: BFsrep29462_CR28
  publication-title: Plos one
  doi: 10.1371/journal.pone.0012743
  contributor:
    fullname: H Egusa
– volume: 5
  start-page: 372
  year: 2011
  ident: BFsrep29462_CR36
  publication-title: Front Med.
  doi: 10.1007/s11684-011-0164-4
  contributor:
    fullname: S Wang
– volume: 46
  start-page: 732
  year: 2010
  ident: BFsrep29462_CR21
  publication-title: Bone
  doi: 10.1016/j.bone.2009.11.003
  contributor:
    fullname: IS Kwun
– volume: 131
  start-page: 861
  year: 2007
  ident: BFsrep29462_CR27
  publication-title: Cell
  doi: 10.1016/j.cell.2007.11.019
  contributor:
    fullname: K Takahashi
– volume: 284
  start-page: 143
  year: 1999
  ident: BFsrep29462_CR35
  publication-title: Science.
  doi: 10.1126/science.284.5411.143
  contributor:
    fullname: MF Pittenger
– volume: 7
  start-page: 89
  year: 2001
  ident: BFsrep29462_CR29
  publication-title: Tissue Eng
  doi: 10.1089/107632700300003323
  contributor:
    fullname: LD Buttery
– volume: 12
  start-page: e114
  year: 2010
  ident: BFsrep29462_CR22
  publication-title: Clin Implant Dent Res
  doi: 10.1111/j.1708-8208.2010.00278.x
  contributor:
    fullname: K Alvarez
– volume: 29
  start-page: 206
  year: 2011
  ident: BFsrep29462_CR31
  publication-title: Stem cells
  doi: 10.1002/stem.566
  contributor:
    fullname: G Bilousova
– volume: 137
  start-page: 1101
  year: 2007
  ident: BFsrep29462_CR20
  publication-title: J Nutr
  doi: 10.1093/jn/137.4.1101
  contributor:
    fullname: KM Hambidge
– volume: 47
  start-page: 396
  year: 1999
  ident: BFsrep29462_CR46
  publication-title: J Biomed Mater Res.
  doi: 10.1002/(SICI)1097-4636(19991205)47:3<396::AID-JBM15>3.0.CO;2-R
  contributor:
    fullname: A Yamamoto
– volume: 67
  start-page: 1115
  year: 2003
  ident: BFsrep29462_CR15
  publication-title: J Biomed Mater Res A.
  doi: 10.1002/jbm.a.10041
  contributor:
    fullname: M Ikeuchi
– volume: 19
  start-page: 38
  year: 2001
  ident: BFsrep29462_CR14
  publication-title: J Bone Miner Metab.
  doi: 10.1007/s007740170058
  contributor:
    fullname: ZJ Ma
– volume: 100
  start-page: 5807
  year: 2003
  ident: BFsrep29462_CR38
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.0937635100
  contributor:
    fullname: M Miura
– volume: 8
  start-page: 455
  year: 2006
  ident: BFsrep29462_CR47
  publication-title: Annu Rev Biomed Eng.
  doi: 10.1146/annurev.bioeng.8.061505.095721
  contributor:
    fullname: AG Robling
– volume: 292
  start-page: 154
  year: 1981
  ident: BFsrep29462_CR23
  publication-title: Nature
  doi: 10.1038/292154a0
  contributor:
    fullname: MJ Evans
– volume: 150
  start-page: 893
  year: 1965
  ident: BFsrep29462_CR48
  publication-title: Science.
  doi: 10.1126/science.150.3698.893
  contributor:
    fullname: MR Urist
– volume: 111
  start-page: 731
  year: 1990
  ident: BFsrep29462_CR55
  publication-title: J. Cell Biol.
  doi: 10.1083/jcb.111.2.731
  contributor:
    fullname: EY Yang
SSID ssj0000529419
Score 2.449889
Snippet Zinc is an essential trace element that plays an important role in differentiation of osteoblasts and bone modeling. This in vitro study aimed to evaluate the...
Abstract Zinc is an essential trace element that plays an important role in differentiation of osteoblasts and bone modeling. This in vitro study aimed to...
Zinc is an essential trace element that plays an important role in differentiation of osteoblasts and bone modeling. This in vitro study aimed to evaluate the...
SourceID pubmedcentral
proquest
crossref
pubmed
SourceType Open Access Repository
Aggregation Database
Index Database
StartPage 29462
SubjectTerms Alkaline Phosphatase - genetics
Alkaline Phosphatase - metabolism
Biomarkers - metabolism
Bone marrow
Cell Differentiation - drug effects
Cell Proliferation - drug effects
Cells, Cultured
Dental pulp
Dental Pulp - cytology
Dental Pulp - drug effects
Dental Pulp - metabolism
Dentistry
Extracellular Matrix - drug effects
Gene expression
Growth factors
Humans
In Vitro Techniques
Mineralization
Osteoblasts - cytology
Osteoblasts - drug effects
Phosphatase
Shear strength
Stem cells
Stem Cells - cytology
Stem Cells - drug effects
Stem Cells - metabolism
Surgery
Titanium
Titanium - chemistry
Transplants & implants
Up-Regulation
Zinc - chemistry
Zinc - pharmacology
SummonAdditionalLinks – databaseName: Proquest Health and Medical Complete
  dbid: 7X7
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwEB6VIgQXVMorUJBBXK1NHNtJTgjRVisOnKi04hI5fqiRaJLuJkj8e2aSTWBB6jW25MTjeL55fQPwoYidieOguLAm59IUjpvESa6C0yFNtBZ-ZPv8qtdX8stGbY5gPdfCUFrlfCeOF7VrLfnIV6SJ0FRAg2ZlKvIC2H71sbvl1D-K4qz7Zhr34H4iEFbgyc422eJtoXiWTIqZWijNV6iAOnymxaFC-g9l_pss-Zf2uTyBx3vYyD5Ncn4CR745hQdTI8lfp_DwnJJ-qG_bU_Df68bym9bVAeEloyKyph5u2G7YBmM98801SXrHqLyjrRA992xuk9JPgmJtYG6sk2Td8KNjRPbMyMW_Y3XDftb9tn0GV5cX3z6v-b6ZArdoAfccL7a0SF2wldHW6QKRjPVSGyUspTpVaChm0iurjPaZL2KfVVUuMiUDIgCHIOQ5HDdt418CK2KlTJDCC-OlMbYqchM7kZJ9G_tER_B-3tGymzgzyjHWneblsu0RnM17Xe5_m135R8gRvFuG8cDTJ5rGtwPNmVgKRRLBi0k0yypUZ4RWdxxBdiC0ZQKRaR-ONPX1SKotEadJlby6-7VewyNETHrM183P4LjfDv4NopK-ejseuN9CWuac
  priority: 102
  providerName: ProQuest
– databaseName: Scholars Portal Open Access Journals
  dbid: M48
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1NT9wwEB0hUCUuqLQFUqByEVdD4thOckAIVUWoUnvqSqiXyPGHiATOspsg-PeMk82KBQ4921GSGcfzXjzzBuC4iI2KYyco0yqnXBWGqsRwKpyRLk2kZLZX-_wjryb817W4XoOxx-bCgPN3qV3oJzWZ3Z483j-d4wd_NpSM56cYS6as4GEn3mA85WGh_16g_EHiG0f7Fh9Be50ihmCjxtDLq1cj0xu4-Tpr8kUYuvwIWwv8SC4Gh2_DmvWf4MPQUfLpM9h_tdf0rjG1Q2xJQgWZr7s7Mu9mTmlLrL8Jbp6TUNvRVAidWzL2SGkHL5HGEdMXSZJpdzslQemZhP_7c1J78lC3s-YLTC5__v1xRRedFKhG-ttS3NXSIjVOV0pqIwuEMdpyqQTTIc-pQpaYcSu0UNJmtohtVlU5ywR3GP4NIpAdWPeNt3tAilgI5TizTFmulK6KXMWGpYHcxjaRERyNViyng2BG2R90p3m5NHUEB6N9y9HlZcAaSAaRskbwfTmMqz28ovK26cKcQaKQJRHsDu5Y3iUUGSHljiPIVhy1nBCUtFdHfH3TK2pzBGlcJF__59n3YRNBk-xTdvMDWG9nnT1EYNJW3_pl9wwGC-US
  priority: 102
  providerName: Scholars Portal
Title Zinc-modified titanium surface enhances osteoblast differentiation of dental pulp stem cells in vitro
URI https://www.ncbi.nlm.nih.gov/pubmed/27387130
https://www.proquest.com/docview/1812249825/abstract/
https://search.proquest.com/docview/1803447521
https://pubmed.ncbi.nlm.nih.gov/PMC4937451
Volume 6
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3fa5xAEB6SlEJfSvrbJD22pa_mdN1d3cckJIRCQigNHH2RdX8QIbfKnRb632dWzyPXvvXFB3dF3Rmd79OZbwC-ycSoJHE8ploVMVPSxCo1LObOCJelQlA7qH3eiut79n3BF3vAp1qYIWlfV_Wpf1ye-vphyK1sl3o-5YnN724uGMZUxtP5PuznWfaMoo-C3lSyVE4qQlkxx1jT4j4ROteEShTkZcluGPoHW_6dIvks5lwdwusNWCRn40W9gT3r38LLsX3kn3dgf9Vex8vG1A6BJAnlYr7ul2Tdr5zSllj_EGy6JqGQo6kQJ3dkaojSjSYhjSNmqIgkbf_YkiDrTMLH_DWpPfldd6vmPdxfXf68uI43bRNijVy3i_EVlsnMOF0poY2QiFm0ZUJxqkNSU4WUMGeWa66Eza1MbF5VBc05cxjrDcKND3DgG28_AZEJ58oxaqmyTCldyUIlhmaBySY2FRF8nVaxbEd1jHL4q50V5XbVIziZ1rfcPCDrMgALZH7ITyP4sh1G1w63qLxt-jBn1COkaQQfR3NszzLZMYJ8x1DbCUE2e3cEvWmQz954z9F_H3kMrxA2iSFptziBg27V288ITbpqhg65yGfw4vzy9u7HbCD4uL1hxWxw0ieGw-xK
link.rule.ids 230,315,733,786,790,870,891,12083,21416,24346,27957,27958,31754,31755,33779,33780,43345,43840,53827,53829,74102,74659
linkProvider National Library of Medicine
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Jb9UwEB5BESqXCsqWUsAgrlYTx3aSU4WA6gGlp1Z64hI5XtRIbRJekkr99_VkgwcS19iSE4_j-Wb7BuBDFhoVhk5QplVKucoMVZHhVDgjXRxJyezA9nkmVxf821qsJ4dbO6VVznficFGbWqOP_Ag1kTcVvEFz3Pyi2DUKo6tTC4378IDHMceUvmSdLD4WjGLxKJsJheL0yKudxj-TbFsN_YMt_06R_EPnnDyGvQksko-jdJ_APVvtw8OxfeTtPux-xlQf7Nb2FOzPstL0ujal86CSYOlYVfbXpO03TmlLbHWJ8m0JFnXUhcfMHZmbo3SjeEjtiBmqI0nTXzUEKZ4JOvZbUlbkpuw29TO4OPly_mlFpxYKVHu7t6P-Oouz2DhdKKmNzDx-0ZZLJZjGBKfCm4cJt0ILJW1is9AmRZGyRHDn9b7x0OM57FR1ZV8CyUIhlOPMMmW5UrrIUhUaFqNVG9pIBvB-3tG8GZky8iHCHaf5su0BHM57nU8_S5v_Fm0A75Zhf8zxE1Vl6x7njNyELArgxSiaZRWsLvK2dhhAsiW0ZQJSaG-PVOXlQKXNPTrjIjr4_2u9hd3V-Y_T_PTr2fdX8MhjJjlk7KaHsNNtevva45KueDMcvjtQNeXP
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1bi9UwEB50Fy8voqur1VWj-BpOmyZp-yTq7mG9cFjEhcWXkubCFty2nraC_95Jb3oUfG0KbTPTzDfJN98AvMpCo8LQCcq0SilXmaEqMpwKZ6SLIymZHdQ-N_L0nH-4EBcT_6mdaJXzmjgs1KbWfo985SMRpgqY0KzcRIs4O16_br5T30HKn7RO7TSuw37CpUAP3397sjn7vOy4-DMtHmWzvFCcrjAINXhNst2g9A_S_Jsw-UcEWt-FOxN0JG9GW9-Da7Y6gBtjM8mfB3Dr2BN_fO-2-2C_lpWmV7UpHUJM4gvJqrK_Im2_dUpbYqtLb-2W-BKPukAE3ZG5VUo3GovUjpihVpI0_beGeMFn4rf5W1JW5EfZbesHcL4--fLulE4NFajGLLijuLjFWWycLpTURmaIZrTlUgmmPd2pwGQx4VZooaRNbBbapChSlgjuEAUYBCKHsFfVlX0EJAuFUI4zy5TlSukiS1VoWOxz3NBGMoCX84zmzaibkQ_n3XGaL9MewNE81_n067T5b0MH8GIZRqf3n6gqW_f-nlGpkEUBPBxNszzF1xph5h0GkOwYbbnBC2rvjlTl5SCszRGrcRE9_v9rPYeb6Hn5p_ebj0_gNgIoOdB30yPY67a9fYogpSueTd73C7rU63I
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Zinc-modified+titanium+surface+enhances+osteoblast+differentiation+of+dental+pulp+stem+cells+in+vitro&rft.jtitle=Scientific+reports&rft.au=Yusa%2C+Kazuyuki&rft.au=Yamamoto%2C+Osamu&rft.au=Takano%2C+Hiroshi&rft.au=Fukuda%2C+Masayuki&rft.date=2016-07-08&rft.issn=2045-2322&rft.eissn=2045-2322&rft.volume=6&rft.issue=1&rft_id=info:doi/10.1038%2Fsrep29462&rft.externalDBID=n%2Fa&rft.externalDocID=10_1038_srep29462
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2045-2322&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2045-2322&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2045-2322&client=summon