Resurgence of pertussis calls for re-evaluation of pertussis animal models

Pertussis has recently re-emerged in well-vaccinated populations most likely due to a combination of pathogen adaptation and waning of vaccine-induced pertussis immunity. Changes in genomic content of the etiologic agent, Bordetella pertussis, observed in the postvaccination era can have a bearing o...

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Published inExpert review of vaccines Vol. 11; no. 9; pp. 1121 - 1137
Main Authors van der Ark, Arno AJ, Hozbor, Daniela F, Boog, Claire JP, Metz, Bernard, van den Dobbelsteen, Germie PJM, van Els, Cécile ACM
Format Journal Article
LanguageEnglish
Published England Taylor & Francis 01.09.2012
Expert Reviews Ltd
Informa Healthcare
Subjects
animal models
Animal models in research
Animals
Bordetella pertussis
Bordetella pertussis - genetics
Bordetella pertussis - immunology
Bordetella pertussis - pathogenicity
Causes of
Communicable Diseases, Emerging - epidemiology
Communicable Diseases, Emerging - immunology
Communicable Diseases, Emerging - prevention & control
disease and pathogen
Health aspects
Humans
immune modulation
Models, Animal
pathogen adaptation
Pertussis Vaccine - immunology
Prevention
re-emerging pertussis
Statistics
vaccine effectiveness
virulence
Whooping Cough - epidemiology
Whooping Cough - immunology
Whooping Cough - prevention & control
Whooping-cough
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Summary:Pertussis has recently re-emerged in well-vaccinated populations most likely due to a combination of pathogen adaptation and waning of vaccine-induced pertussis immunity. Changes in genomic content of the etiologic agent, Bordetella pertussis, observed in the postvaccination era can have a bearing on the efficacy of vaccines currently in use. Moreover, protective immune responses in vaccinees wane gradually depending on their originally induced size and breadth, and memory responses may not be as regularly boosted by circulating strains as was the case in the prevaccination era. This pertussis scenario asks for new, improved vaccines with at least a longer duration of protection. Pertussis vaccine research, development and postmarketing surveillance require re-evaluation and innovation of the currently available pertussis animal models, with emphasis on the use of circulating B. pertussis strains.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Review-1
ISSN:1476-0584
1744-8395
DOI:10.1586/erv.12.83