Escherichia coli O157:H7 tir 255 T > A allele strains differ in chromosomal and plasmid composition
Shiga toxin-producing (STEC) O157:H7 strains with the T allele in the translocated intimin receptor polymorphism ( ) 255 A > T gene associate with human disease more than strains with an A allele; however, the allele is not thought to be the direct cause of this difference. We sequenced a diverse...
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Published in | Frontiers in microbiology Vol. 14; p. 1303387 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
Switzerland
Frontiers Media S.A
15.12.2023
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Subjects | |
Online Access | Get full text |
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Summary: | Shiga toxin-producing
(STEC) O157:H7 strains with the T allele in the translocated intimin receptor polymorphism (
) 255 A > T gene associate with human disease more than strains with an A allele; however, the allele is not thought to be the direct cause of this difference. We sequenced a diverse set of STEC O157:H7 strains (26% A allele, 74% T allele) to identify linked differences that might underlie disease association. The average chromosome and pO157 plasmid size and gene content were significantly greater within the
255 A allele strains. Eighteen coding sequences were unique to
255 A allele chromosomes, and three were unique to
255 T allele chromosomes. There also were non-pO157 plasmids that were unique to each
255 allele variant. The overall average number of prophages did not differ between
255 allele strains; however, there were different types between the strains. Genomic and mobile element variation linked to the
255 polymorphism may account for the increased frequency of the T allele isolates in human disease. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Edited by: Ben Pascoe, University of Oxford, United Kingdom Reviewed by: Shaimaa Mouftah, Zewail City of Science and Technology, Egypt; Yujie Hu, China National Center for Food Safety Risk Assessment, China |
ISSN: | 1664-302X 1664-302X |
DOI: | 10.3389/fmicb.2023.1303387 |