Akkermansia muciniphila : a potential candidate for ameliorating metabolic diseases
Metabolic diseases are comprehensive disease based on obesity. Numerous cumulative studies have shown a certain correlation between the fluctuating abundance of and the occurrence of metabolic diseases. , a potential probiotic candidate colonized in the human intestinal mucus layer, and its derivati...
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Published in | Frontiers in immunology Vol. 15; p. 1370658 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
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Frontiers Media S.A
20.03.2024
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Abstract | Metabolic diseases are comprehensive disease based on obesity. Numerous cumulative studies have shown a certain correlation between the fluctuating abundance of
and the occurrence of metabolic diseases.
, a potential probiotic candidate colonized in the human intestinal mucus layer, and its derivatives have various physiological functions, including treating metabolic disorders and maintaining human health. This review systematically explicates the abundance change rules of
in metabolic diseases. It also details the high efficacy and specific molecules mechanism of
and its derivatives in treating obesity, type 2 diabetes mellitus, cardiovascular disease, and non-alcoholic fatty liver disease. |
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AbstractList | Metabolic diseases are comprehensive disease based on obesity. Numerous cumulative studies have shown a certain correlation between the fluctuating abundance of
and the occurrence of metabolic diseases.
, a potential probiotic candidate colonized in the human intestinal mucus layer, and its derivatives have various physiological functions, including treating metabolic disorders and maintaining human health. This review systematically explicates the abundance change rules of
in metabolic diseases. It also details the high efficacy and specific molecules mechanism of
and its derivatives in treating obesity, type 2 diabetes mellitus, cardiovascular disease, and non-alcoholic fatty liver disease. Metabolic diseases are comprehensive disease based on obesity. Numerous cumulative studies have shown a certain correlation between the fluctuating abundance of Akkermansia muciniphila and the occurrence of metabolic diseases. A. muciniphila, a potential probiotic candidate colonized in the human intestinal mucus layer, and its derivatives have various physiological functions, including treating metabolic disorders and maintaining human health. This review systematically explicates the abundance change rules of A. muciniphila in metabolic diseases. It also details the high efficacy and specific molecules mechanism of A. muciniphila and its derivatives in treating obesity, type 2 diabetes mellitus, cardiovascular disease, and non-alcoholic fatty liver disease. Metabolic diseases are comprehensive disease based on obesity. Numerous cumulative studies have shown a certain correlation between the fluctuating abundance of Akkermansia muciniphila and the occurrence of metabolic diseases. A. muciniphila , a potential probiotic candidate colonized in the human intestinal mucus layer, and its derivatives have various physiological functions, including treating metabolic disorders and maintaining human health. This review systematically explicates the abundance change rules of A. muciniphila in metabolic diseases. It also details the high efficacy and specific molecules mechanism of A. muciniphila and its derivatives in treating obesity, type 2 diabetes mellitus, cardiovascular disease, and non-alcoholic fatty liver disease. |
Author | Xu, Xiaoyun Niu, Huifang Zogona, Daniel Cui, Dandan Zhou, Minfeng Liang, Fengxia Xing, Zheng Chen, Rui Wu, Ting |
AuthorAffiliation | 2 Union Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology , Wuhan, Hubei , China 1 Key Laboratory of Environment Correlative Dietology (Ministry of Education), Hubei Key Laboratory of Fruit Vegetable Processing Quality Control (Huazhong Agricultural University), School of Food Science and Technology, Huazhong Agricultural University , Wuhan, Hubei , China 3 School of Acupuncture and Bone Injury, Hubei University of Chinese Medicine , Wuhan , China |
AuthorAffiliation_xml | – name: 3 School of Acupuncture and Bone Injury, Hubei University of Chinese Medicine , Wuhan , China – name: 1 Key Laboratory of Environment Correlative Dietology (Ministry of Education), Hubei Key Laboratory of Fruit Vegetable Processing Quality Control (Huazhong Agricultural University), School of Food Science and Technology, Huazhong Agricultural University , Wuhan, Hubei , China – name: 2 Union Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology , Wuhan, Hubei , China |
Author_xml | – sequence: 1 givenname: Huifang surname: Niu fullname: Niu, Huifang organization: Key Laboratory of Environment Correlative Dietology (Ministry of Education), Hubei Key Laboratory of Fruit Vegetable Processing Quality Control (Huazhong Agricultural University), School of Food Science and Technology, Huazhong Agricultural University, Wuhan, Hubei, China – sequence: 2 givenname: Minfeng surname: Zhou fullname: Zhou, Minfeng organization: Union Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China – sequence: 3 givenname: Daniel surname: Zogona fullname: Zogona, Daniel organization: Key Laboratory of Environment Correlative Dietology (Ministry of Education), Hubei Key Laboratory of Fruit Vegetable Processing Quality Control (Huazhong Agricultural University), School of Food Science and Technology, Huazhong Agricultural University, Wuhan, Hubei, China – sequence: 4 givenname: Zheng surname: Xing fullname: Xing, Zheng organization: Key Laboratory of Environment Correlative Dietology (Ministry of Education), Hubei Key Laboratory of Fruit Vegetable Processing Quality Control (Huazhong Agricultural University), School of Food Science and Technology, Huazhong Agricultural University, Wuhan, Hubei, China – sequence: 5 givenname: Ting surname: Wu fullname: Wu, Ting organization: Key Laboratory of Environment Correlative Dietology (Ministry of Education), Hubei Key Laboratory of Fruit Vegetable Processing Quality Control (Huazhong Agricultural University), School of Food Science and Technology, Huazhong Agricultural University, Wuhan, Hubei, China – sequence: 6 givenname: Rui surname: Chen fullname: Chen, Rui organization: Union Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China – sequence: 7 givenname: Dandan surname: Cui fullname: Cui, Dandan organization: Union Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China – sequence: 8 givenname: Fengxia surname: Liang fullname: Liang, Fengxia organization: School of Acupuncture and Bone Injury, Hubei University of Chinese Medicine, Wuhan, China – sequence: 9 givenname: Xiaoyun surname: Xu fullname: Xu, Xiaoyun organization: Key Laboratory of Environment Correlative Dietology (Ministry of Education), Hubei Key Laboratory of Fruit Vegetable Processing Quality Control (Huazhong Agricultural University), School of Food Science and Technology, Huazhong Agricultural University, Wuhan, Hubei, China |
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Copyright | Copyright © 2024 Niu, Zhou, Zogona, Xing, Wu, Chen, Cui, Liang and Xu. Copyright © 2024 Niu, Zhou, Zogona, Xing, Wu, Chen, Cui, Liang and Xu 2024 Niu, Zhou, Zogona, Xing, Wu, Chen, Cui, Liang and Xu |
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Keywords | health Akkermansia muciniphila metabolic diseases gut microbiota obesity |
Language | English |
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Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 Edited by: Subash Babu, International Centers for Excellence in Research (ICER), India Suganthi Balasubramanian, International Centers for Excellence in Research (ICER), India Reviewed by: Anuradha Rajamanickam, International Centers for Excellence in Research (ICER), India |
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