Mussel-inspired nanoparticle composite hydrogels for hemostasis and wound healing

Uncontrolled hemorrhage caused by trauma can easily lead to death. Efficient and safe hemostatic materials are an urgent and increasing need for hemostatic research. Following a trauma, wound healing is induced by various cellular mechanisms and proteins. Hemostatic biomaterials that can not only ha...

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Published inFrontiers in chemistry Vol. 11; p. 1154788
Main Authors Cui, Guihua, Guo, Xiaoyu, Su, Ping, Zhang, Tianshuo, Guan, Jiao, Wang, Chungang
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 30.03.2023
Subjects
Chemistry
hemostasis
hydrogels
mussel-inspired
nanomaterials
wound healing
wound healing
hydrogels
mussel-inspired
nanomaterials
hemostasis
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Summary:Uncontrolled hemorrhage caused by trauma can easily lead to death. Efficient and safe hemostatic materials are an urgent and increasing need for hemostatic research. Following a trauma, wound healing is induced by various cellular mechanisms and proteins. Hemostatic biomaterials that can not only halt bleeding quickly but also provide an environment to promote wound healing have been the focus of research in recent years. Mussel-inspired nanoparticle composite hydrogels have been propelling the development of hemostatic materials owing to their unique advantages in adhesion, hemostasis, and bacteriostasis. This review summarizes the hemostatic and antimicrobial fundamentals of polydopamine (PDA)-based nanomaterials and emphasizes current developments in hemorrhage-related PDA nanomaterials. Moreover, it briefly discusses safety concerns and clinical application problems with PDA hemostatic nanomaterials.
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Ananthakrishnan Soundaram Jeevarathinam, University of Texas MD Anderson Cancer Center, United States
Lincy Varghese, National Taiwan University of Science and Technology, Taiwan
Reviewed by: Haile Fentahun Darge, National Taiwan University of Science and Technology, Taiwan
Edited by: Adhimoorthy Prasannan, National Taiwan University of Science and Technology, Taiwan
This article was submitted to Polymer Chemistry, a section of the journal Frontiers in Chemistry
ISSN:2296-2646
2296-2646
DOI:10.3389/fchem.2023.1154788