Issues in pharmacotherapy of 2009 H1N1 influenza infection

• Published in: Journal of postgraduate medicine Vol. 56; no. 4; pp. 321 - 327
• Main Authors: Gupta, Y K, Padhy, B M
• Format: Journal Article
• Language: English
• Published: India Medknow Publications and Media Pvt. Ltd 01.10.2010; Medknow Publications & Media Pvt. Ltd
• Subjects: Antiviral Agents - pharmacology; Antiviral Agents - supply & distribution; Avian flu; Drug therapy; FDA approval; Gene expression; Humans; India; Influenza A Virus, H1N1 Subtype - drug effects; Influenza Vaccines - supply & distribution; Influenza Vaccines - therapeutic use; Influenza, Human - drug therapy; Influenza, Human - virology; Metabolic disorders; Neuraminidase - antagonists & inhibitors; Neuraminidase - supply & distribution; Oseltamivir - pharmacology; Oseltamivir - supply & distribution; Pandemics; Respiratory diseases; Studies; Swine flu; Swine influenza; Viruses; Zanamivir - pharmacology; Zanamivir - supply & distribution; India
• ISSN: 0022-3859; 0972-2823
• DOI: 10.4103/0022-3859.70945

The pandemic caused by the 2009 H1N1 influenza A virus has been a cause of great concern for healthcare professionals and the scientific community worldwide. Due to the widespread resistance of the virus to adamantanes, pharmacotherapy is currently limited to neuraminidase inhibitors, oseltamivir and zanamivir. The use of neuraminidase inhibitors in India is primarily associated with issues of patient and physician awareness, variability in disease management guidelines, safety and efficacy in the Indian population, need for active drug safety monitoring, and development of resistance due to possible misuse. In addition, other issues like availability of the drugs in retail and stockpiling by the public health authorities need careful introspection. The development of influenza vaccines in India and its adequate availability to the country's populace also poses significant challenges in the management of the pandemic. In light of the limited therapeutic options available for the management of the disease, research on novel targets and pharmacological agents would also be beneficial in addressing the challenges of future outbreaks.