Exosomal miRNAs as novel avenues for breast cancer treatment

Breast cancer is the most commonly diagnosed cancer and a leading cause of death in women worldwide. It is a heterogeneous disease, as shown by the gene expression profiles of breast cancer samples. It begins in milk-producing ducts, with a high degree of diversity between and within tumors, as well...

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Published inFrontiers in genetics Vol. 14; p. 1134779
Main Authors Singh, Tejveer, Kaushik, Mahesh, Mishra, Lokesh Chandra, Behl, Chesta, Singh, Vijay, Tuli, Hardeep Singh
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 22.03.2023
Subjects
breast cancer
diagnosis
exosome
Genetics
metastasis
miRNA
breast cancer
diagnosis
miRNA
metastasis
exosome
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Summary:Breast cancer is the most commonly diagnosed cancer and a leading cause of death in women worldwide. It is a heterogeneous disease, as shown by the gene expression profiles of breast cancer samples. It begins in milk-producing ducts, with a high degree of diversity between and within tumors, as well as among cancer-bearing individuals. The enhanced prevalence of breast cancer is influenced by various hormonal, lifestyle, and environmental factors, and very early onset of the disease correlates strongly with the risk of local and distant recurrence. Many subtypes are difficult to treat with conventional therapeutic modalities, and therefore, optimal management and early diagnosis are the first steps to minimizing the mortality linked with breast cancer. The use of newer methods of nanotechnology extends beyond the concept of synthesizing drug delivery mechanisms into the creation of new therapeutics, such as delivering chemotherapeutics with nanomaterial properties. Exosomes, a class of nanovesicles, are emerging as novel tools for deciphering the patient-specific proteins and biomarkers across different disease models, including breast cancer. In this review, we address the role of exosomal miRNA in breast cancer diagnosis and treatment.
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Nemat Ali, King Saud University, Saudi Arabia
Manohar Prasad Bhandari, University of Latvia, Latvia
Shoib Baba, Department of Education, India
Edited by: Manoj Kumar Kashyap, Amity University Gurgaon, India
This article was submitted to RNA, a section of the journal Frontiers in Genetics
Reviewed by: Ankit Verma, Hebrew University of Jerusalem, Israel
ISSN:1664-8021
1664-8021
DOI:10.3389/fgene.2023.1134779