Emerging Role of LY6E in Virus-Host Interactions

As a canonical lymphocyte antigen-6/urokinase-type plasminogen activator receptor Ly6/uPAR family protein, lymphocyte antigen 6 complex, locus E (LY6E), plays important roles in immunological regulation, T cell physiology, and oncogenesis. Emerging evidence indicates that LY6E is also involved in th...

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Published inViruses Vol. 11; no. 11; p. 1020
Main Authors Yu, Jingyou, Liu, Shan-Lu
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 03.11.2019
MDPI
Subjects
Adenoviruses
Antigens
Chromosomes
Cloning
Dengue fever
Fibroblasts
Gene expression
Genes
Genotype & phenotype
HIV
Human immunodeficiency virus
Immune system
Infections
Influenza
Lipids
ly6/upar
ly6e
Lymphocytes
Lymphocytes T
Pathogenesis
Proteins
Review
Tumorigenesis
U-Plasminogen activator
Viral infections
Viruses
virus–host interactions
viruses
virus–host interactions
LY6E
Ly6/uPAR
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Summary:As a canonical lymphocyte antigen-6/urokinase-type plasminogen activator receptor Ly6/uPAR family protein, lymphocyte antigen 6 complex, locus E (LY6E), plays important roles in immunological regulation, T cell physiology, and oncogenesis. Emerging evidence indicates that LY6E is also involved in the modulation of viral infection. Consequently, viral infection and associated pathogenesis have been associated with altered LY6E gene expression. The interaction between viruses and the host immune system has offered insights into the biology of LY6E. In this review, we summarize the current knowledge of LY6E in the context of viral infection, particularly viral entry.
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Present address: Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.
ISSN:1999-4915
1999-4915
DOI:10.3390/v11111020