Recent applications of click chemistry for the functionalization of gold nanoparticles and their conversion to glyco-gold nanoparticles

• Published in: Beilstein journal of organic chemistry Vol. 14; no. 1; pp. 11 - 24
• Main Authors: Poonthiyil, Vivek, Lindhorst, Thisbe K, Golovko, Vladimir B, Fairbanks, Antony J
• Format: Journal Article
• Language: English
• Published: Germany Beilstein-Institut zur Föerderung der Chemischen Wissenschaften 2018; Beilstein-Institut
• Subjects: azide–alkyne Huisgen cycloaddition; Carbohydrates; Catalysis; Chemistry; click chemistry; glyco-gold nanoparticles; Gold; Ligands; Methods; Nanoparticles; Physicochemical properties; Proteins; Review; triazole; New Zealand; carbohydrates; click chemistry; glyco-gold nanoparticles; azide–alkyne Huisgen cycloaddition; triazole
• ISSN: 1860-5397; 2195-951X; 1860-5397
• DOI: 10.3762/bjoc.14.2

Glycoscience, despite its myriad of challenges, promises to unravel the causes of, potential new detection methods for, and novel therapeutic strategies against, many disease states. In the last two decades, glyco-gold nanoparticles have emerged as one of several potential new tools for glycoscientists. Glyco-gold nanoparticles consist of the unique structural combination of a gold nanoparticle core and an outer-shell comprising multivalent presentation of carbohydrates. The combination of the distinctive physicochemical properties of the gold core and the biological function/activity of the carbohydrates makes glyco-gold nanoparticles a valuable tool in glycoscience. In this review we present recent advances made in the use of one type of click chemistry, namely the azide-alkyne Huisgen cycloaddition, for the functionalization of gold nanoparticles and their conversion to glyco-gold nanoparticles.