Diversity of immune checkpoints in cancer immunotherapy

Finding effective treatments for cancer remains a challenge. Recent studies have found that the mechanisms of tumor evasion are becoming increasingly diverse, including abnormal expression of immune checkpoint molecules on different immune cells, in particular T cells, natural killer cells, macropha...

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Published inFrontiers in immunology Vol. 14; p. 1121285
Main Authors Guo, Zhangyan, Zhang, Rui, Yang, An-Gang, Zheng, Guoxu
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 07.03.2023
Subjects
Humans
immune checkpoint
Immunology
Immunotherapy
Killer Cells, Natural
macrophage
Molecular Targeted Therapy
Neoplasms - pathology
NK cell
T cell
T-Lymphocytes - metabolism
macrophage
T cell
NK cell
immune checkpoint
immunotherapy
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Summary:Finding effective treatments for cancer remains a challenge. Recent studies have found that the mechanisms of tumor evasion are becoming increasingly diverse, including abnormal expression of immune checkpoint molecules on different immune cells, in particular T cells, natural killer cells, macrophages and others. In this review, we discuss the checkpoint molecules with enhanced expression on these lymphocytes and their consequences on immune effector functions. Dissecting the diverse roles of immune checkpoints in different immune cells is crucial for a full understanding of immunotherapy using checkpoint inhibitors.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
Edited by: Julie Decock, Qatar Biomedical Research Institute, Qatar
Reviewed by: Wolfram Weckwerth, University of Vienna, Austria; Pierosandro Tagliaferri, Magna Græcia University, Italy
This article was submitted to Cancer Immunity and Immunotherapy, a section of the journal Frontiers in Immunology
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2023.1121285