Piezo channels in the intestinal tract

The intestine is the largest mechanosensitive organ in the human body whose epithelial cells, smooth muscle cells, neurons and enteroendocrine cells must sense and respond to various mechanical stimuli such as motility, distension, stretch and shear to regulate physiological processes including dige...

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Published inFrontiers in physiology Vol. 15; p. 1356317
Main Authors He, Haolong, Zhou, Jingying, Xu, Xuan, Zhou, Pinxi, Zhong, Huan, Liu, Mi
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 06.02.2024
Subjects
intestinal tract
mechanosensation
mechanosensitive ion channels
Physiology
Piezo1
Piezo2
mechanosensitive ion channels
Piezo2
Piezo1
intestinal tract
mechanosensation
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Summary:The intestine is the largest mechanosensitive organ in the human body whose epithelial cells, smooth muscle cells, neurons and enteroendocrine cells must sense and respond to various mechanical stimuli such as motility, distension, stretch and shear to regulate physiological processes including digestion, absorption, secretion, motility and immunity. Piezo channels are a newly discovered class of mechanosensitive ion channels consisting of two subtypes, Piezo1 and Piezo2. Piezo channels are widely expressed in the intestine and are involved in physiological and pathological processes. The present review summarizes the current research progress on the expression, function and regulation of Piezo channels in the intestine, with the aim of providing a reference for the future development of therapeutic strategies targeting Piezo channels.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
Reviewed by: Yaopeng Hu, Fukuoka University, Japan
Volodymyr Tsvilovskyy, Heidelberg University, Germany
Edited by: Michael L. Jennings, University of Arkansas for Medical Sciences, United States
ISSN:1664-042X
1664-042X
DOI:10.3389/fphys.2024.1356317