Label-Free Aptasensors for the Detection of Mycotoxins

Various methodologies have been reported in the literature for the qualitative and quantitative monitoring of mycotoxins in food and feed samples. Based on their enhanced specificity, selectivity and versatility, bio-affinity assays have inspired many researchers to develop sensors by exploring bio-...

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Bibliographic Details
Published inSensors (Basel, Switzerland) Vol. 16; no. 12; p. 2178
Main Authors Rhouati, Amina, Catanante, Gaelle, Nunes, Gilvanda, Hayat, Akhtar, Marty, Jean-Louis
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 18.12.2016
MDPI
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Summary:Various methodologies have been reported in the literature for the qualitative and quantitative monitoring of mycotoxins in food and feed samples. Based on their enhanced specificity, selectivity and versatility, bio-affinity assays have inspired many researchers to develop sensors by exploring bio-recognition phenomena. However, a significant problem in the fabrication of these devices is that most of the biomolecules do not generate an easily measurable signal upon binding to the target analytes, and signal-generating labels are required to perform the measurements. In this context, aptamers have been emerged as a potential and attractive bio-recognition element to design label-free aptasensors for various target analytes. Contrary to other bioreceptor-based approaches, the aptamer-based assays rely on antigen binding-induced conformational changes or oligomerization states rather than binding-assisted changes in adsorbed mass or charge. This review will focus on current designs in label-free conformational switchable design strategies, with a particular focus on applications in the detection of mycotoxins.
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ISSN:1424-8220
1424-8220
DOI:10.3390/s16122178