Gender differences in the association between HTR2C gene variants and suicidal behavior in a Mexican population: a case-control study
The aim of this case-control study was to explore the association by gender between the gene variants and suicidal behavior in a Mexican population. A total of 183 suicide attempters and 208 healthy volunteers were included in this study. We genotyped five polymorphisms of HTR2C (rs547536, rs2192372...
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Published in | Neuropsychiatric disease and treatment Vol. 13; pp. 559 - 566 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
New Zealand
Dove Medical Press Limited
01.01.2017
Taylor & Francis Ltd Dove Medical Press |
Subjects | |
Online Access | Get full text |
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Summary: | The aim of this case-control study was to explore the association by gender between the
gene variants and suicidal behavior in a Mexican population.
A total of 183 suicide attempters and 208 healthy volunteers were included in this study. We genotyped five polymorphisms of HTR2C (rs547536, rs2192372, rs4272555, rs6318, and rs2428707), then measured the association by genotype, allele, and haplotype.
In the female group, we found an association between two polymorphisms of the HTR2C (rs4272555 and rs2428707) and suicide attempts. The C allele of the single-nucleotide polymorphism (SNP) rs4272555 was associated with a decreased risk of suicide attempt (
=0.01, odds ratio =0.26, 95% confidence interval: 0.09-0.79), whereas the G allele of the SNP rs2428707 was associated with an increased risk of suicide attempt (
=0.01, odds ratio =3.68, 95% confidence interval: 1.24-10.90). No significant association was observed between the other polymorphisms studied (rs547536, rs2192372, rs6318) or haplotypes with suicide attempts.
These findings suggest a possible risk factor of the
gene in the pathology of suicidal behavior in Mexican population. More studies are necessary to confirm this association. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1176-6328 1178-2021 1178-2021 |
DOI: | 10.2147/NDT.S122024 |