Japanese encephalitis virus: from genome to infectome

• Published in: Microbes and infection Vol. 13; no. 4; pp. 312 - 321
• Main Authors: Unni, Salini Krishnan, Růžek, Daniel, Chhatbar, Chintan, Mishra, Ritu, Johri, Manish K., Singh, Sunit K.
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier SAS 01.04.2011; Elsevier
• Subjects: Animals; Arboviral encephalitis; Arboviral infections; Arboviroses; Arbovirus; Biological and medical sciences; Culex; Encephalitis Virus, Japanese - classification; Encephalitis Virus, Japanese - genetics; Encephalitis Virus, Japanese - immunology; Encephalitis Virus, Japanese - pathogenicity; Encephalitis, Japanese - pathology; Encephalitis, Japanese - prevention & control; Encephalitis, Japanese - therapy; Flaviviridae; Fundamental and applied biological sciences. Psychology; Genome, Viral - genetics; Human viral diseases; Humans; Immunity; Infectious diseases; Japanese encephalitis; Japanese encephalitis virus; Medical sciences; Microbiology; Miscellaneous; Mosquito borne infections; Neuropathogenesis; Neurotropic infection; Tropical viral diseases; Viral diseases; Virology; Virus Replication - physiology; Neuropathogenesis; Mosquito borne infections; Neurotropic infection; Japanese encephalitis; Arboviral infections; Nervous system diseases; Flavivirus; Cerebral disorder; Infection; Virus; Viral disease; Arbovirus disease; Central nervous system disease; Japanese encephalitis virus; Japanese encephalitis group virus; Flaviviridae; Genome
• ISSN: 1286-4579; 1769-714X
• DOI: 10.1016/j.micinf.2011.01.002

Japanese encephalitis virus (JEV) is an arbovirus belonging to the family Flaviviridae. It is maintained in a zoonotic cycle involving pigs, ardeid birds and Culex species of mosquitoes. Humans are accidental/dead end hosts of JEV infection because they cannot sustain high viral titers. Factors affecting the clinical manifestations and pathogenesis of JEV infection are not well understood. Though, vaccines are currently available against JEV, it has to be further improved. Here we review the literature on the JEV life cycle, pathogenesis and host immune responses to JEV infection.