Controlling the Mdm2-Mdmx-p53 Circuit

• Published in: Pharmaceuticals Vol. 3; no. 5; pp. 1576 - 1593
• Main Authors: Waning, David L, Lehman, Jason A, Batuello, Christopher N, Mayo, Lindsey D
• Format: Journal Article Book Review
• Language: English
• Published: Switzerland MDPI AG 18.05.2010; MDPI
• Subjects: kinase inhibitor; Mdm2; Mdmx; p53; phosphorylation; Review

The p53 tumor suppressor is a key protein in maintaining the integrity of the genome by inducing either cell cycle arrest or apoptosis following cellular stress signals. Two human family members, Mdm2 and Mdmx, are primarily responsible for inactivating p53 transcription and targeting p53 protein fo...