Autoantibodies Against the Fibrinolytic Receptor, Annexin A2, in Cerebral Venous Thrombosis

• Published in: Stroke (1970) Vol. 42; no. 2; pp. 501 - 503
• Main Authors: CESARMAN-MAUS, Gabriela, CANTU-BRITO, Carlos, BARINAGARREMENTERIA, Fernando, VILLA, Rosario, REYES, Elba, SANCHEZ-GUERRERO, Jorge, HAJJAR, Katherine A, GARCIA LATORRE, Ethel
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 01.02.2011
• Subjects: Adolescent; Adult; Annexin A2 - immunology; Autoantibodies - biosynthesis; Biological and medical sciences; Biomarkers - blood; Female; Fibrinolysis - immunology; Humans; Intracranial Thrombosis - blood; Intracranial Thrombosis - diagnosis; Intracranial Thrombosis - immunology; Male; Medical sciences; Middle Aged; Neurology; Neuropharmacology; Neuroprotective agent; Pharmacology. Drug treatments; Prospective Studies; Vascular diseases and vascular malformations of the nervous system; Venous Thrombosis - blood; Venous Thrombosis - diagnosis; Venous Thrombosis - immunology; Young Adult; Autoimmunity; Hypercoagulability; Immunopathology; Stroke; Nervous system diseases; Antiphospholipid antibody syndrome; cerebral venous thrombosis; Autoimmune disease; Cardiovascular disease; annexin A2; Hemopathy; Cerebral disorder; Venous disease; Encephalon; Vascular disease; Thrombophilia; antiphospholipid syndrome; Platelet; Central nervous system disease; Venous thrombosis; Coagulopathy; Fibrinolytic; Cerebrovascular disease
• ISSN: 0039-2499; 1524-4628; 1524-4628
• DOI: 10.1161/STROKEAHA.110.592121

Cerebral venous thrombosis (CVT) may be a manifestation of underlying autoimmune disease. Antibodies against annexin A2 (anti-A2Ab) coincide with antiphospholipid syndrome, in which antiphospholipid antibodies (aPLA) are associated with thrombosis in any vascular bed. Annexin A2, a profibrinolytic receptor and binding site for β2-glycoprotein-I, the main target for aPLA, is highly expressed on cerebral endothelium. Here we evaluate the prevalence of anti-A2Ab in CVT. Forty individuals with objectively documented CVT (33 women and 7 men) and 145 healthy controls were prospectively studied for hereditary and acquired prothrombotic risk factors, classical aPLA, and anti-A2Ab. One or more prothrombotic risk factors were found in 85% of CVT subjects, (pregnancy/puerperium in 57.5%, classical aPLA in 22.5%, and hereditary procoagulant risk factors in 17.5%). Anti-A2Ab (titer >3 SD) were significantly more prevalent in patients with CVT (12.5%) than in healthy individuals (2.1%, P<0.01, OR, 5.9). Anti-A2Ab are significantly associated with CVT and may define a subset of individuals with immune-mediated cerebral thrombosis.