The regulation of lncRNAs and miRNAs in SARS-CoV-2 infection

The coronavirus disease 2019 (COVID-19) was a global endemic that continues to cause a large number of severe illnesses and fatalities. There is increasing evidence that non-coding RNAs (ncRNAs) are crucial regulators of viral infection and antiviral immune response and the role of non-coding RNAs i...

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Published inFrontiers in cell and developmental biology Vol. 11; p. 1229393
Main Authors Lin, Yuhao, Sun, Qiqi, Zhang, Bao, Zhao, Wei, Shen, Chenguang
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 27.07.2023
Subjects
Cell and Developmental Biology
COVID-19
lncRNA
mechanism
miRNA
non-coding RNA
SARS-CoV-2
COVID-19
miRNA
SARS-CoV-2
lncRNA
non-coding RNA
mechanism
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Summary:The coronavirus disease 2019 (COVID-19) was a global endemic that continues to cause a large number of severe illnesses and fatalities. There is increasing evidence that non-coding RNAs (ncRNAs) are crucial regulators of viral infection and antiviral immune response and the role of non-coding RNAs in SARS-CoV-2 infection has now become the focus of scholarly inquiry. After SARS-CoV-2 infection, some ncRNAs’ expression levels are regulated to indirectly control the expression of antiviral genes and viral gene replication. However, some other ncRNAs are hijacked by SARS-CoV-2 in order to help the virus evade the immune system by suppressing the expression of type I interferon (IFN-1) and controlling cytokine levels. In this review, we summarize the recent findings of long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) among non-coding RNAs in SARS-CoV-2 infection and antiviral response, discuss the potential mechanisms of actions, and prospects for the detection, treatment, prevention and future directions of SARS-CoV-2 infection research.
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Edited by: Shoulong Deng, Chinese Academy of Medical Sciences and Peking Union Medical College, China
These authors have contributed equally to this work
Reviewed by: Qingbing Zheng, Xiamen University, China
Yang Yang, Shenzhen Third People’s Hospital, China
ISSN:2296-634X
2296-634X
DOI:10.3389/fcell.2023.1229393