Geno3D: automatic comparative molecular modelling of protein

• Published in: Bioinformatics Vol. 18; no. 1; pp. 213 - 214
• Main Authors: Combet, Christophe, Jambon, Martin, Deléage, Gilbert, Geourjon, Christophe
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.01.2002; Oxford Publishing Limited (England); Oxford University Press (OUP)
• Subjects: Algorithms; Biochemistry, Molecular Biology; Biological and medical sciences; Computational Biology; Computer Simulation; Fundamental and applied biological sciences. Psychology; General aspects; Internet; Life Sciences; Mathematics in biology. Statistical analysis. Models. Metrology. Data processing in biology (general aspects); Models, Molecular; Proteins - chemistry; Sequence Alignment - statistics & numerical data; Sequence Homology, Amino Acid; Three dimensional structure; Sequence alignment; Homology; Web site; Bioinformatics; Modeling; Protein; Aminoacid sequence
• ISSN: 1367-4803; 1460-2059; 1367-4811
• DOI: 10.1093/bioinformatics/18.1.213

Geno3D (http://geno3d-pbil.ibcp.fr) is an automatic web server for protein molecular modelling. Starting with a query protein sequence, the server performs the homology modelling in six successive steps: (i) identify homologous proteins with known 3D structures by using PSI-BLAST; (ii) provide the user all potential templates through a very convenient user interface for target selection; (iii) perform the alignment of both query and subject sequences; (iv) extract geometrical restraints (dihedral angles and distances) for corresponding atoms between the query and the template; (v) perform the 3D construction of the protein by using a distance geometry approach and (vi) finally send the results by e-mail to the user. Availability: Free to academic users http://geno3d-pbil.ibcp.fr Contact: c.geourjon@ibcp.fr * To whom correspondence should be addressed.