Role of regulation of PD-1 and PD-L1 expression in sepsis

Long term immunosuppression is problematic during sepsis. The PD-1 and PD-L1 immune checkpoint proteins have potent immunosuppressive functions. Recent studies have revealed several features of PD-1 and PD-L1 and their roles in sepsis. Here, we summarize the overall findings of PD-1 and PD-L1 by fir...

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Published inFrontiers in immunology Vol. 14; p. 1029438
Main Authors Zhang, Teng, Yu-Jing, Li, Ma, Tao
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 09.03.2023
Subjects
B7-H1 Antigen - metabolism
Humans
immune cells
Immune Tolerance
Immunology
Immunosuppression Therapy
PD-1
PD-L1
Programmed Cell Death 1 Receptor - metabolism
Sepsis
PD-L1
immune cells
PD-1
immunology
sepsis
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Summary:Long term immunosuppression is problematic during sepsis. The PD-1 and PD-L1 immune checkpoint proteins have potent immunosuppressive functions. Recent studies have revealed several features of PD-1 and PD-L1 and their roles in sepsis. Here, we summarize the overall findings of PD-1 and PD-L1 by first reviewing the biological features of PD-1 and PD-L1 and then discussing the mechanisms that control the expression of PD-1 and PD-L1. We then review the functions of PD-1 and PD-L1 in physiological settings and further discuss PD-1 and PD-L1 in sepsis, including their involvement in several sepsis-related processes and their potential therapeutic relevance in sepsis. In general, PD-1 and PD-L1 have critical roles in sepsis, indicating that their regulation may be a potential therapeutic target for sepsis.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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Edited by: Ian Marriott, University of North Carolina at Charlotte, United States
Reviewed by: Parizad Torabi-Parizi, National Institutes of Health, United States; Zahra Hosseini-khah, Mazandaran University of Medical Sciences, Iran
This article was submitted to Microbial Immunology, a section of the journal Frontiers in Immunology
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2023.1029438