Analysis of the spectrum and antibiotic resistance of uropathogens in vitro: Results based on a retrospective study from a tertiary hospital

• Published in: American journal of infection control Vol. 41; no. 7; pp. 601 - 606
• Main Authors: Ma, Kun Ling, MD, PhD, Wang, Chang Xian, MD
• Format: Journal Article
• Language: English
• Published: New York, NY Mosby, Inc 01.07.2013; Elsevier; Mosby-Year Book, Inc
• Subjects: Actinobacteria - drug effects; Aged; Aged, 80 and over; Anti-Bacterial Agents - therapeutic use; Antibacterial agents; Antibiotics; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antimicrobial resistance; Bacterial infections; Biological and medical sciences; China; Community-Acquired Infections - drug therapy; Community-Acquired Infections - microbiology; Community-acquired urinary tract infection; Cross Infection - drug therapy; Cross Infection - microbiology; Drug resistance; Drug Resistance, Bacterial; E coli; Enterococcus - drug effects; Epidemiology. Vaccinations; Escherichia coli - drug effects; Female; General aspects; Human infectious diseases. Experimental studies and models; Humans; Infection Control; Infectious Disease; Infectious diseases; Klebsiella Infections - drug therapy; Klebsiella pneumoniae - drug effects; Male; Medical sciences; Middle Aged; Nosocomial urinary tract infection; Pharmacology. Drug treatments; Proteus mirabilis - drug effects; Retrospective Studies; Tertiary Care Centers; Urinary tract diseases; Urinary Tract Infections - drug therapy; Urinary Tract Infections - microbiology; China; Nosocomial urinary tract infection; Community-acquired urinary tract infection; Antimicrobial resistance; Nosocomial infection; Urinary system disease; Drug susceptibility test; Check; Urinary tract disease; In vitro; Prevention; Resistance; Antibiotic; Urinary tract infection; Community acquired infection; Hospital; Antibacterial agent
• ISSN: 0196-6553; 1527-3296
• DOI: 10.1016/j.ajic.2012.09.015

Background Antibiotic resistance of uropathogens in urinary tract infections (UTIs) is increasing worldwide. This study aimed to compare the spectrum and antimicrobial resistance of uropathogens in community-acquired UTIs (CAUTIs) and nosocomial-acquired UTIs (NAUTIs) at a tertiary hospital in China. Methods Retrospective analysis of uropathogens from UTI patients was performed at Zhong Da Hospital. Results A total of 1129 strains was isolated from 653 community-acquired and 476 nosocomial-acquired infections. Escherichia coli was the most common uropathogen, accounting for 55.9% of the CAUTIs and 27.1% of the NAUTIs. Among the CAUTIs, Escherichia coli was followed in prevalence by Enterococcus spp (12.9%) and Proteus mirabilis (3.7%). Among the NAUTIs, Escherichia coli was followed by Enterococcus spp (15.3%) and Klebsiella pneumoniae (6.9%). The proportion of fungi in the NAUTIs (23.7%) was higher than that in the CAUTIs (3.1%) ( P < .05). Extended-spectrum β-lactamase-producing strains of E coli accounted for 70.6% of the NAUTIs and 47.3% of the CAUTIs. Carbapenems, amikacin, and nitrofurantoin were active agents against E coli . The resistance rates of E coli to cephalosporins, ampicillin, ampicillin/sulbactam, quinolones, and gentamicin were higher in the NAUTIs than in the CAUTIs ( P < .05). Conclusion The distribution of species was different between CAUTIs and NAUTIs. Higher antibiotic resistance rates were observed in the NAUTIs than in the CAUTIs.