The Amount of Hepatocyte Turnover That Occurred during Resolution of Transient Hepadnavirus Infections Was Lower When Virus Replication Was Inhibited with Entecavir

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Published inJournal of Virology Vol. 83; no. 4; pp. 1778 - 1789
Main Authors MASON, William S, CHUNXIAO XU, HUEY CHI LOW, SAPUTELLI, Jeffry, ALDRICH, Carol E, SCOUGALL, Catherine, GROSSE, Arend, COLONNO, Richard, LITWIN, Sam, JILBERT, Allison R
Format Journal Article
LanguageEnglish
Published Washington, DC American Society for Microbiology 01.02.2009
American Society for Microbiology (ASM)
Subjects
Animals
Antiviral Agents - therapeutic use
Biological and medical sciences
DNA, Viral - analysis
Fundamental and applied biological sciences. Psychology
Guanine - analogs & derivatives
Guanine - therapeutic use
Hepadnavirus
Hepatitis B - drug therapy
Hepatitis B - pathology
Hepatitis B - virology
Hepatitis B Virus, Woodchuck - drug effects
Hepatocytes - chemistry
Hepatocytes - virology
Liver Regeneration
Marmota
Microbiology
Miscellaneous
Pathogenesis and Immunity
Virology
Virus Replication - drug effects
Woodchuck hepatitis virus
Infection
Hepatocyte
Viral disease
Entecavir
Turnover
Antiviral
Replication
In vitro
Virology
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Present address: Presidio Pharmaceuticals, Inc., 1700 Owens Street, Suite 585, San Francisco, CA 94158.
Corresponding author. Mailing address for William S. Mason: Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111. Phone: (215) 728-2462. Fax: (215) 728-2412. E-mail: ws_mason@fccc.edu. Mailing address for Allison R. Jilbert: School of Molecular and Biomedical Science, University of Adelaide, Adelaide SA 5005, Australia. Phone: 61-8-8303 5399. Fax: 61-8-8303 7532. E-mail: allison.jilbert@adelaide.edu.au
Present address: Drexel Institute for Biotechnology and Virology Research of Drexel University College of Medicine, Pennsylvania Biotechnology Center, 3805 Old Easton Road, Doylestown, PA 18902.
ISSN:0022-538X
1098-5514
DOI:10.1128/JVI.01587-08