Role of MOTS-c in the regulation of bone metabolism

MOTS-c, a mitochondrial-derived peptide (MDP), is an essential regulatory mediator of cell protection and energy metabolism and is involved in the development of specific diseases. Recent studies have revealed that MOTS-c promotes osteoblast proliferation, differentiation, and mineralization. Furthe...

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Published inFrontiers in physiology Vol. 14; p. 1149120
Main Authors Yi, Xuejie, Hu, Guangxuan, Yang, Yang, Li, Jing, Jin, Junjie, Chang, Bo
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 02.05.2023
Subjects
bone
metabolism
MOTS-c
movement presentation
osteoblast
osteoclast
Physiology
MOTS-c
bone
metabolism
osteoblast
osteoclast
movement presentation
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Summary:MOTS-c, a mitochondrial-derived peptide (MDP), is an essential regulatory mediator of cell protection and energy metabolism and is involved in the development of specific diseases. Recent studies have revealed that MOTS-c promotes osteoblast proliferation, differentiation, and mineralization. Furthermore, it inhibits osteoclast production and mediates the regulation of bone metabolism and bone remodeling. Exercise effectively upregulates the expression of MOTS-c, but the specific mechanism of MOTS-c regulation in bone by exercise remains unclear. Therefore, this article reviewed the distribution and function of MOTS-c in the tissue, discussed the latest research developments in the regulation of osteoblasts and osteoclasts, and proposed potential molecular mechanisms for the effect of exercise on the regulation of bone metabolism. This review provides a theoretical reference for establishing methods to prevent and treat skeletal metabolic diseases.
Bibliography:ObjectType-Article-2
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Edited by: Zhaojing Chen, California State University, United States
Zhi Xia, Wenzhou University, China
These authors contributed equally to this work and share first authorship
Reviewed by: Seungyong Lee, Incheon National University, Republic of Korea
ISSN:1664-042X
1664-042X
DOI:10.3389/fphys.2023.1149120