Pattern recognition receptors in zebrafish provide functional and evolutionary insight into innate immune signaling pathways

Pattern recognition receptors （PRRs） and their signaling pathways have essential roles in recognizing various components of pathogens as well as damaged cells and triggering inflammatory responses that eliminate invading microorganisms and damaged cells. The zebrafish relies heavily on these primary...

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Bibliographic Details
Published inCellular & molecular immunology Vol. 14; no. 1; pp. 80 - 89
Main Authors Li, Yajuan, Li, Yuelong, Cao, Xiaocong, Jin, Xiangyu, Jin, Tengchuan
Format Journal Article
LanguageEnglish
Published China Nature Publishing Group 01.01.2017
Subjects
Amino Acid Sequence
Animals
Base Sequence
Biological Evolution
Humans
Immunity, Innate
Inflammasomes - metabolism
Receptors, Pattern Recognition - metabolism
Review
Signal Transduction - immunology
Zebrafish - immunology
信号通路
先天免疫
免疫防御机制
受体
受损细胞
斑马鱼
模式识别
进化关系
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Summary:Pattern recognition receptors （PRRs） and their signaling pathways have essential roles in recognizing various components of pathogens as well as damaged cells and triggering inflammatory responses that eliminate invading microorganisms and damaged cells. The zebrafish relies heavily on these primary defense mechanisms against pathogens. Here, we review the major PRR signaling pathways in the zebrafish innate immune system and compare these signaling pathways in zebrafish and humans to reveal their evolutionary relationship and better understand their innate immune defense mechanisms.
Bibliography:11-4987/R
Pattern recognition receptors （PRRs） and their signaling pathways have essential roles in recognizing various components of pathogens as well as damaged cells and triggering inflammatory responses that eliminate invading microorganisms and damaged cells. The zebrafish relies heavily on these primary defense mechanisms against pathogens. Here, we review the major PRR signaling pathways in the zebrafish innate immune system and compare these signaling pathways in zebrafish and humans to reveal their evolutionary relationship and better understand their innate immune defense mechanisms.
caspases; innate immune system; NOD-like receptors; pattern recognition receptor; RIG-I-like receptors; Toll-like receptors; zebrafish
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ISSN:1672-7681
2042-0226
DOI:10.1038/cmi.2016.50