A Mechanically-Adaptive Polymer Nanocomposite-Based Intracortical Probe and Package for Chronic Neural Recording

Mechanical, materials, and biological causes of intracortical probe failure have hampered their utility in basic science and clinical applications. By anticipating causes of failure, we can design a system that will prevent the known causes of failure. The neural probe design was centered around a b...

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Bibliographic Details
Published inMicromachines (Basel) Vol. 9; no. 11; p. 583
Main Authors Hess-Dunning, Allison, Tyler, Dustin J
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 08.11.2018
MDPI
Subjects
Arrays
bio-inspired
Biomimetics
Cellulose
cellulose nanocrystals
Circuit design
Electrochemical impedance spectroscopy
Failure
Interfaces
intracortical
Memory
Microelectrodes
Nanocomposites
Nanocrystals
neural probe
Packaging
Parylene C
photolithography
Physiology
Polyethylene glycol
polymer nanocomposite
Polymers
Recording
Softening
Three dimensional printing
Transplants & implants
photolithography
microelectrodes
polymer nanocomposite
neural probe
intracortical
Parylene C
bio-inspired
cellulose nanocrystals
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Summary:Mechanical, materials, and biological causes of intracortical probe failure have hampered their utility in basic science and clinical applications. By anticipating causes of failure, we can design a system that will prevent the known causes of failure. The neural probe design was centered around a bio-inspired, mechanically-softening polymer nanocomposite. The polymer nanocomposite was functionalized with recording microelectrodes using a microfabrication process designed for chemical and thermal process compatibility. A custom package based upon a ribbon cable, printed circuit board, and a 3D-printed housing was designed to enable connection to external electronics. Probes were implanted into the primary motor cortex of Sprague-Dawley rats for 16 weeks, during which regular recording and electrochemical impedance spectroscopy measurement sessions took place. The implanted mechanically-softening probes had stable electrochemical impedance spectra across the 16 weeks and single units were recorded out to 16 weeks. The demonstration of chronic neural recording with the mechanically-softening probe suggests that probe architecture, custom package, and general design strategy are appropriate for long-term studies in rodents.
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ISSN:2072-666X
2072-666X
DOI:10.3390/mi9110583