A Novel Method Based on GAN Using a Segmentation Module for Oligodendroglioma Pathological Image Generation

• Published in: Sensors (Basel, Switzerland) Vol. 22; no. 10; p. 3960
• Main Authors: Kweon, Juwon, Yoo, Jisang, Kim, Seungjong, Won, Jaesik, Kwon, Soonchul
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 23.05.2022; MDPI
• Subjects: Algorithms; Brain cancer; Datasets; Deep learning; digital pathology; generative adversarial networks; Medical imaging; Morphology; Noise; Pathology; pathology image synthesis; generative adversarial networks; digital pathology; pathology image synthesis
• ISSN: 1424-8220; 1424-8220
• DOI: 10.3390/s22103960

Digital pathology analysis using deep learning has been the subject of several studies. As with other medical data, pathological data are not easily obtained. Because deep learning-based image analysis requires large amounts of data, augmentation techniques are used to increase the size of pathological datasets. This study proposes a novel method for synthesizing brain tumor pathology data using a generative model. For image synthesis, we used embedding features extracted from a segmentation module in a general generative model. We also introduce a simple solution for training a segmentation model in an environment in which the masked label of the training dataset is not supplied. As a result of this experiment, the proposed method did not make great progress in quantitative metrics but showed improved results in the confusion rate of more than 70 subjects and the quality of the visual output.