Gender difference in acquired seizure susceptibility in adult rats after early complex febrile seizures

Gender differences are involved in many neurological disorders including epilepsy. However, little is known about the effect of gender difference on the risk of epilepsy in adults with a specific early pathological state such as complex febrile seizures（FSs） in infancy. Here we used a well-establish...

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Published inNeuroscience bulletin Vol. 30; no. 6; pp. 913 - 922
Main Authors Dai, Yun-Jian, Xu, Zheng-Hao, Feng, Bo, Xu, Ceng-Lin, Zhao, Hua-Wei, Wu, Deng-Chang, Hu, Wei-Wei, Chen, Zhong
Format Journal Article
LanguageEnglish
Published Singapore Springer Singapore 01.12.2014
Subjects
Anatomy
Anesthesiology
Animals
Biomedical and Life Sciences
Biomedicine
Convulsants
Disease Models, Animal
Disease Susceptibility
Electroshock
Female
Fever
Human Physiology
Male
Neurology
Neurosciences
Original
Original Article
Pain Medicine
Pentylenetetrazole
Rats
Seizures - etiology
Sex Characteristics
性别差异
惊厥
成年大鼠
收购
敏感性
早期
癫痫
高热
epilepsy
complex febrile seizures
gender difference
seizure susceptibility
IL-1β
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Summary:Gender differences are involved in many neurological disorders including epilepsy. However, little is known about the effect of gender difference on the risk of epilepsy in adults with a specific early pathological state such as complex febrile seizures（FSs） in infancy. Here we used a well-established complex FS model in rats and showed that：（1） the susceptibility to seizures induced by hyperthermia, pentylenetetrazol（PTZ）, and maximal electroshock（MES） was similar in male and female rat pups, while males were more susceptible to PTZ- and MES-induced seizures than age-matched females in normal adult rats;（2） adult rats with complex FSs in infancy acquired higher seizure susceptibility than normal rats; importantly, female FS rats were more susceptible to PTZ and MES than male FS rats; and（3） the protein expression of interleukin-1β, an infl ammatory factor associated with seizure susceptibility, was higher in adult FS females than in males, which may reflect a gender-difference phenomenon of seizure susceptibility. Our results provide direct evidence that the acquired seizure susceptibility after complex FSs is gender-dependent.
Bibliography:31-1975/R
Gender differences are involved in many neurological disorders including epilepsy. However, little is known about the effect of gender difference on the risk of epilepsy in adults with a specific early pathological state such as complex febrile seizures（FSs） in infancy. Here we used a well-established complex FS model in rats and showed that：（1） the susceptibility to seizures induced by hyperthermia, pentylenetetrazol（PTZ）, and maximal electroshock（MES） was similar in male and female rat pups, while males were more susceptible to PTZ- and MES-induced seizures than age-matched females in normal adult rats;（2） adult rats with complex FSs in infancy acquired higher seizure susceptibility than normal rats; importantly, female FS rats were more susceptible to PTZ and MES than male FS rats; and（3） the protein expression of interleukin-1β, an infl ammatory factor associated with seizure susceptibility, was higher in adult FS females than in males, which may reflect a gender-difference phenomenon of seizure susceptibility. Our results provide direct evidence that the acquired seizure susceptibility after complex FSs is gender-dependent.
gender difference;complex febrile seizures;seizure susceptibility;epilepsy;IL-1β
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1673-7067
1995-8218
1995-8218
DOI:10.1007/s12264-014-1482-8