Role of casein phosphopeptide amorphous calcium phosphate in remineralization of white spot lesions and inhibition of Streptococcus mutans?

• Published in: Journal of conservative dentistry Vol. 16; no. 4; pp. 342 - 346
• Main Authors: Vashisht, Ruchi, Indira, Rajamani, Ramachandran, S, Kumar, Anil, Srinivasan, Manali
• Format: Journal Article
• Language: English
• Published: India Medknow Publications 01.07.2013; Medknow Publications and Media Pvt. Ltd; Medknow Publications & Media Pvt. Ltd; Medknow Publications & Media Pvt Ltd
• Subjects: Calcium phosphate; Calcium phosphates; Clinical outcomes; Composition; Dentifrices; Dentistry; Original; Physiological aspects; Prevention; Risk factors; Streptococcal infections; India; remineralization; enamel; white-spotlesions; Casein phosphopeptide-amorphous calcium phosphate
• ISSN: 0972-0707; 2950-4716; 2950-4708; 0974-5203
• DOI: 10.4103/0972-0707.114370

Introduction: To promote the remineralization by ionic exchange mechanism instead of invasive techniques many remineralizing agents can be used. Objective: To evaluate the remineralization effects of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) on white spot lesions (WSLs) and its inhibitory effect on Streptococcus mutans colonization. Materials and Methods: The study group consisted of 60 subjects exhibiting at least 1-WSL. Subjects were randomly divided into 2 groups: A test group using CPP-ACP cream (GC-Tooth Mousse, Leuven, Belgium) and a control group using only fluoride containing toothpaste for a period of 3-month. Baseline WSLs were scored using DIAGNOdent device (KaVo Germany) and the saliva samples were collected to measure S. mutans counts. After the 3-month period the WSLs were again recorded and the saliva collection was repeated. Result: DIAGNOdent measurements were increased by time (P = 0.002) in the control group and no statistically significant difference (P = 0.217) was found in the test group by the 3-month period. In both groups, the mutans counts were decreased in the 3-month experimental period. Conclusion: These clinical and laboratory results suggested that CPP-ACP containing cream had a slight remineralization effect on the WSL in the 3-month evaluation period however, longer observation is recommended to confirm whether the greater change in WSLs is maintained.