Neuronal antinuclear antibody (anti-Hu) in paraneoplastic encephalomyelitis simulating acute polyneuritis

A patient with paraneoplastic encephalomyelitis (PEM) and small cell lung cancer had a clinical presentation of acute polyneuritis. The patient had an antibody (anti-Hu) restricted to nuclei of neurons identical to that reported in patients with subacute sensory neuronopathy and lung cancer. This fi...

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Bibliographic Details
Published inActa neurologica Scandinavica Vol. 75; no. 4; p. 249
Main Authors Graus, F, Elkon, K B, Lloberes, P, Ribalta, T, Torres, A, Ussetti, P, Valls, J, Obach, J, Agusti-Vidal, A
Format Journal Article
LanguageEnglish
Published Denmark 01.04.1987
Subjects
Antibodies, Antinuclear - analysis
Carcinoma, Small Cell - immunology
Diagnosis, Differential
Encephalomyelitis - diagnosis
Encephalomyelitis - immunology
Ganglia, Spinal - pathology
Humans
Lung Neoplasms - immunology
Male
Middle Aged
Neurons - immunology
Paraneoplastic Syndromes - diagnosis
Paraneoplastic Syndromes - immunology
Polyneuropathies - diagnosis
Spinal Cord - pathology
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Summary:A patient with paraneoplastic encephalomyelitis (PEM) and small cell lung cancer had a clinical presentation of acute polyneuritis. The patient had an antibody (anti-Hu) restricted to nuclei of neurons identical to that reported in patients with subacute sensory neuronopathy and lung cancer. This finding further supports the hypothesis that PEM and subacute sensory neuronopathy are closely related disorders of autoimmune origin. PEM should be considered in patients with small cell lung cancer and clinical features limited to the peripheral nervous system.
ISSN:0001-6314
DOI:10.1111/j.1600-0404.1987.tb07928.x