Preparation of a stationary phase with quaternary ammonium embedded group for selective separation of alkaloids based on ion-exclusion interaction

• Published in: Journal of separation science Vol. 35; no. 20; pp. 2685 - 2692
• Main Authors: Liu, Qiaoxia, Liang, Tu, Li, Kuiyong, Ke, Yanxiong, Jin, Yu, Liang, Xinmiao
• Format: Journal Article
• Language: English
• Published: Weinheim Blackwell Publishing Ltd 01.10.2012; Wiley; Wiley Subscription Services, Inc
• Subjects: Alkaloids; Alkaloids - chemistry; Alkaloids - isolation & purification; Biological and medical sciences; Chains; Chromatography; Chromatography, Liquid - instrumentation; Chromatography, Liquid - methods; Cortex phellodendri; Cortexes; General pharmacology; Hydrophobic and Hydrophilic Interactions; Immobilization; Ion-exclusion; Medical sciences; Mixed-mode chromatography (MMC); Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Polymers; Quaternary Ammonium Compounds - chemistry; Quaternary ammonium embedded stationary phase; Resins, Synthetic - chemical synthesis; Resins, Synthetic - chemistry; Separation; Asia; China; Tandem mass spectrometry; Chemical analysis; Organic cation; Rutaceae; Bark; Mobile phase; Retention time; Ion exchange chromatography; Medicinal plant; Alkaloids; Alkaloid; Folk medicine; Dicotyledones; Phellodendron amurense; Angiospermae; pH; Mixed-mode chromatography (MMC); Ion exchange resin; Coupled method; Pharmacognosy; Phellodendron chinense; Quaternary ammonium compound; Ion-exclusion; Quaternary ammonium embedded stationary phase; Preparation; Plant origin; Spermatophyta; Mixed adsorbent; Bonded stationary phase; Cortex phellodendri

A stationary phase (named QA C10) with quaternary ammonium embedded between a propyl and a decyl chain was synthesized by immobilization of N,N‐dimethyldecylamine on chloropropyl–silica surface. A set of representative neutral, basic, and acidic compounds was employed to evaluate its chromatographic...