Clinical features of Sjogren's syndrome in patients with multiple sclerosis

• Published in: Acta neurologica Scandinavica Vol. 124; no. 2; pp. 109 - 114
• Main Authors: Annunziata, P., De Santi, L., Di Rezze, S., Millefiorini, E., Capello, E., Mancardi, G., De Riz, M., Scarpini, E., Vecchio, R., Patti, F.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.08.2011; Blackwell
• Subjects: Adult; Antirheumatic Agents - therapeutic use; Biological and medical sciences; Cross-Sectional Studies; Disability Evaluation; Female; glatiramer acetate; Humans; immunomodulatory therapies; interferon beta; Interferon-beta - therapeutic use; Magnetic Resonance Imaging; Male; Medical sciences; Multiple sclerosis; Multiple Sclerosis - cerebrospinal fluid; Multiple Sclerosis - complications; Multiple Sclerosis - diagnosis; Multiple Sclerosis - drug therapy; Nervous system involvement in other diseases. Miscellaneous; Neurology; Observation; Retrospective Studies; Severity of Illness Index; Sjogren's syndrome; Sjogren's Syndrome - cerebrospinal fluid; Sjogren's Syndrome - complications; Sjogren's Syndrome - diagnosis; Sjogren's Syndrome - drug therapy; Surveys and Questionnaires; Human; interferon beta; Immunopathology; Therapy; Nervous system diseases; Multiple sclerosis; Sjogren's syndrome; immunomodulatory therapies; Stomatology; Autoimmune disease; glatiramer acetate; Sjögren syndrome; Inflammatory disease; Eye disease; Treatment; Systemic disease; Central nervous system disease; Beta interferon
• ISSN: 0001-6314; 1600-0404
• DOI: 10.1111/j.1600-0404.2010.01428.x

Annunziata P, De Santi L, Di Rezze S, Millefiorini E, Capello E, Mancardi G, De Riz M, Scarpini E, Vecchio R, Patti F. Clinical features of Sjogren’s syndrome in patients with multiple sclerosis. 
Acta Neurol Scand: 2011: 124: 109–114.
© 2010 John Wiley & Sons A/S. Objectives –  To assess the frequency of clinical features of Sjogren’s syndrome (SS) in patients with multiple sclerosis (MS) receiving treatment with disease‐modifying drugs (DMDs) or naïve to treatment and the possible association with clinical, cerebrospinal fluid (CSF) and magnetic resonance imaging (MRI) parameters. Methods –  A multicentre cross‐sectional observational study was designed, based on a structured neurologist‐administered questionnaire to 440 patients. Results –  Twenty‐eight of 230 (12%) patients receiving treatment with DMDs (DMDs+) and 14 of 210 (6.6%) treatment‐naïve patients (DMDs−) showed clinical features of SS. Four primary SS were diagnosed, two of which were DMDs+ and two were DMDs−. Sicca symptoms were significantly associated with higher EDSS scores (P = 0.018), a low frequency of gadolinium‐enhanced MRI‐positive lesions (P = 0.018) and cerebral disturbances (P = 0.001). Conclusions –  Screening for the clinical features of SS should be performed in patients with MS both receiving treatment with immunomodulatory drugs and without therapy.