Diencephalic seizures: responsiveness to bromocriptine and morphine

Two patients with posttraumatic diencephalic seizures, characterized by autonomic dysfunction and extensor posturing, had partial responses to bromocriptine and complete responses to morphine. Probable synergism between the two agents was noted. These 2 cases suggest the potential effectiveness of t...

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Bibliographic Details
Published inAnnals of neurology Vol. 21; no. 6; p. 609
Main Author Bullard, D E
Format Journal Article
LanguageEnglish
Published United States 01.06.1987
Subjects
Adult
Brain - physiopathology
Bromocriptine - therapeutic use
Diencephalon
Dopamine - physiology
Endorphins - physiology
Epilepsy, Post-Traumatic - drug therapy
Epilepsy, Post-Traumatic - physiopathology
Humans
Male
Morphine - therapeutic use
Synaptic Transmission
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Summary:Two patients with posttraumatic diencephalic seizures, characterized by autonomic dysfunction and extensor posturing, had partial responses to bromocriptine and complete responses to morphine. Probable synergism between the two agents was noted. These 2 cases suggest the potential effectiveness of this regimen for the treatment of diencephalic seizures, raise questions regarding the role of the dopaminergic and opioid systems in this disease entity, and support the hypothesis that diencephalic seizures represent a release phenomenon in the brain.
ISSN:0364-5134
DOI:10.1002/ana.410210617