Cytosine arabinoside and cisplatin for advanced breast cancer. A phase II study of the cancer and leukemia group B
Forty‐four women with advanced breast cancer participated in a prospective clinical trial to evaluate the efficacy and toxicity of a regimen consisting of cytosine arabinoside and cisplatin. All patients had previously received chemotherapy. Three patients (7%) responded to therapy with response dur...
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Published in | Cancer Vol. 68; no. 8; pp. 1696 - 1698 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
New York
Wiley Subscription Services, Inc., A Wiley Company
15.10.1991
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Subjects | |
Online Access | Get full text |
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Summary: | Forty‐four women with advanced breast cancer participated in a prospective clinical trial to evaluate the efficacy and toxicity of a regimen consisting of cytosine arabinoside and cisplatin. All patients had previously received chemotherapy. Three patients (7%) responded to therapy with response durations of 153, 160, and 441 days. The median time to disease progression and median survival time in all 44 patients were 2.3 and 5 months, respectively. This regimen had significant toxicity, with most patients experiencing severe or life‐threatening hematologic, renal, or infectious complications. This regimen cannot be recommended for previously treated patients with advanced breast cancer. |
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ISSN: | 0008-543X 1097-0142 |
DOI: | 10.1002/1097-0142(19911015)68:8<1696::AID-CNCR2820680807>3.0.CO;2-B |