Mesoporous silica/organosilica nanoparticles for cancer immunotherapy

• Published in: Exploration (Beijing, China) Vol. 3; no. 3; pp. 20220086 - n/a
• Main Authors: Theivendran, Shevanuja, Lazarev, Sergei, Yu, Chengzhong
• Format: Journal Article
• Language: English
• Published: China John Wiley & Sons, Inc 01.06.2023; Wiley
• Subjects: Cancer; Cancer immunotherapy; Cancer therapies; Drug delivery systems; Hydrocarbons; Immunotherapy; Morphology; Nanoparticles; Nanotechnology; organosilica; Pore size; Side effects; Silica; Silicon dioxide; Surfactants; Synergism; Tumor microenvironment; cancer; organosilica; nanoparticles; silica; immunotherapy
• ISSN: 2766-8509; 2766-2098; 2766-2098
• DOI: 10.1002/EXP.20220086

Cancer is one of the fatal diseases in the history of humankind. In this regard, cancer immunotherapeutic strategies have revolutionized the traditional mode of cancer treatment. Silica based nano‐platforms have been extensively applied in nanomedicine including cancer immunotherapy. Mesoporous silica nanoparticles (MSN) and mesoporous organosilica nanoparticles (MON) are attractive candidates due to the ease in controlling the structural parameters as needed for the targeted immunotherapeutic applications. Especially, the MON provide an additional advantage of controlling the composition and modulating the biological functions to actively synergize with other immunotherapeutic strategies. In this review, the applications of MSN, MON, and metal‐doped MSN/MON in the field of cancer immunotherapy and tumor microenvironment regulation are comprehensively summarized by highlighting the structural and compositional attributes of the silica‐based nanoplatforms. Silica based nanoparticles have been extensively applied in nanomedicine including cancer immunotherapy. In this review, the applications of mesoporous silica nanoparticles (MSN), mesoporous organosilica nanoparticles (MON), and metal‐doped MSN/MON in the field of cancer immunotherapy and tumor microenvironment regulation are comprehensively summarized by highlighting the structural and compositional attributes of the silica‐based nanoplatforms.