Serum Sirtuin1 level decreases in Parkinson's disease and vascular parkinsonism: A prospective observational study

• Published in: Clinical neurology and neurosurgery Vol. 225; p. 107595
• Main Authors: Li, Yifeng, Zhang, Chengmei, Xu, Wei, Chen, Jihua, Tuo, Jia, Wen, Ying, Huang, Zhongxiong, Zeng, Rong
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.02.2023; Elsevier Limited
• Subjects: Age; Basal ganglia; Biomarkers; Body mass index; Brain diseases; Central nervous system diseases; Clinical significance; Cognitive ability; Diagnostic biomarker; Enzyme-linked immunosorbent assay; Humans; Interleukin 6; Movement disorders; Neurodegenerative diseases; Neurological disorders; Neurology; Neurosurgery; Observational studies; Observational Studies as Topic; Oxidative stress; Parkinson Disease - diagnosis; Parkinson Disease, Secondary - diagnosis; Parkinson's disease; Patients; Prospective Studies; Regression analysis; Risk factors; SIRT1; SIRT1 protein; Sirtuin 1; Statistical analysis; Tumor necrosis factor-TNF; UPDRS; Vascular Diseases; Vascular parkinsonism; CRP; ChE; Parkinson's disease; IL; SIRT1; CMRGlc; Diagnostic biomarker; NAD; TNF- α; Hoehn-Yahr; PD; UPDRSIII; NMS; MMSE; TFF3; UPDRS; VP; NMSS; Vascular parkinsonism; ApoE-KO; MDS; ELISA; hcy; BMI; modified Hoehn and Yahr staging scale; C-reactive protein; tumor necrosis factor α; cholinesterase; Interleukin; cerebral glucose metabolic rate; movement disorder society; nicotinamide adenine dinucleotide; apolipoprotein E-knockout; unified Parkinson's disease rating scale III; Sirtuin1; homocysteine; Body Mass Index; non-motor symptoms; Trefoil factor 3; Non-Motor Symptoms Scale; enzyme-linked immunosorbent assay; mini-mental state examination
• ISSN: 0303-8467; 1872-6968; 1872-6968
• DOI: 10.1016/j.clineuro.2023.107595

The present study aimed to investigate levels and clinical significance of serum SIRT1 in Parkinson's disease (PD) and Vascular parkinsonism (VP). This prospective observational research enrolled a total of 165 VP and 159 PD patients who were admitted during March 2018 to December 2021. Blood samples and medical characteristics were also obtained from 160 healthy volunteers. The serum Sirtuin1 (SIRT1) and cytokines levels of all subjects were measured by enzyme-linked immunosorbent assay (ELISA) method. Demographic and clinical data were also collected. Statistical analysis was conducted using SPSS software with P < 0.05 as statistically different. The mean age, the UPDRSIII score of VP patients was significantly higher compared with the PD patients (p<0.05), while the MMSE score of VP patients was significantly lower than the PD patients (p<0.001). The serum SIRT1 levels of the VP patients were remarkably lower than the PD patients or the healthy persons (p<0.05). Pearson’s analysis showed that SIRT1 levels were negatively correlated with levels of IL-6, TNF- α and hcy. The UPDRSIII of SIRT1 low levels group was remarkably higher than the SIRT1 high levels group (p=0.048), while the MMSE score was lower than the SIRT1 high levels group (p<0.001). In addition, ROC curves showed that SIRT1 could be a potential diagnostic biomarker of VP. SIRT1 was a risk factor for VP. Our present study indicated that SIRT1 associated with disease severity and could discriminate PD from VP. ●Serum SIRT1 levels were remarkably decreased in VP patients.●SIRT1 levels were negatively correlated with levels of IL-6, TNF- α and hcy.●SIRT1 associated with disease severity and could discriminate PD from VP.