Platelet function in patients with major depression
Depression, ischaemic heart disease and cerebrovascular disease are important causes of morbidity and are among the leading contributors to global health burden. These conditions often occur in the same patient, resulting in considerably greater effect on health than combinations of chronic diseases...
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Published in | Internal medicine journal Vol. 39; no. 1; pp. 38 - 43 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Melbourne, Australia
Blackwell Publishing Asia
01.01.2009
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Subjects | |
Online Access | Get full text |
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Summary: | Depression, ischaemic heart disease and cerebrovascular disease are important causes of morbidity and are among the leading contributors to global health burden. These conditions often occur in the same patient, resulting in considerably greater effect on health than combinations of chronic diseases without depression. The frequent occurrence of these conditions in the same patient raises the possibility of a common genetic predisposition, similar risk factors or a pathophysiological link. Serotoninergic and adrenergic signalling play important roles in causing major depression and also in platelet activation and aggregation, which underlies vascular disease. This review discusses the potential pathophysiological link between major depression and conditions in which platelet activation plays an important role and also provides evidence linking the use of the most commonly used antidepressant drugs (i.e. the selective serotonin re‐uptake inhibitors) to increased risk of bleeding. |
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Bibliography: | ArticleID:IMJ1794 istex:C5DB3C6A4E994FB2E57C43ADB56CE72F8AFC593F ark:/67375/WNG-SQXKDCWH-Z Funding: Dr Ziegelstein is supported by grant number R24AT004641 from the National Center for Complementary and Alternative Medicine and by the Miller Family Scholar Programme. Potential conflicts of interest: The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Center for Complementary & Alternative Medicine or the National Institutes of Health. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-3 ObjectType-Review-1 |
ISSN: | 1444-0903 1445-5994 |
DOI: | 10.1111/j.1445-5994.2008.01794.x |