Cytomegalovirus infection and schizencephaly: case reports

Two children with left open-lip schizencephaly are reported. Cytomegalovirus (CMV) infection was demonstrated on the second day of life in Patient 1; in the other patient CMV infection was observed at the age of 4 years. Magnetic resonance imaging revealed polymicrogyric cortex lining the clefts. In...

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Bibliographic Details
Published inAnnals of neurology Vol. 43; no. 1; p. 123
Main Authors Iannetti, P, Nigro, G, Spalice, A, Faiella, A, Boncinelli, E
Format Journal Article
LanguageEnglish
Published United States 01.01.1998
Subjects
Brain - diagnostic imaging
Brain - pathology
Calcinosis - diagnostic imaging
Cerebral Cortex - abnormalities
Cerebral Cortex - virology
Cytomegalovirus - genetics
Cytomegalovirus Infections - complications
Cytomegalovirus Infections - virology
DNA - genetics
DNA, Viral - analysis
Ependyma - diagnostic imaging
Genes, Homeobox - genetics
Homeodomain Proteins - genetics
Humans
Infant
Magnetic Resonance Imaging
Male
Mutation
Nerve Tissue Proteins - genetics
Polymorphism, Single-Stranded Conformational
Tomography, X-Ray Computed
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Summary:Two children with left open-lip schizencephaly are reported. Cytomegalovirus (CMV) infection was demonstrated on the second day of life in Patient 1; in the other patient CMV infection was observed at the age of 4 years. Magnetic resonance imaging revealed polymicrogyric cortex lining the clefts. In Patient 2 polymicrogyria was also present in the corresponding area contralateral to the schizencephaly. Computed tomography revealed the presence of subependymal periventricular calcifications. Genetic analysis did not demonstrate the presence of EMX2 homeobox gene. The possible role of CMV infection in the complex multifactorial pathogenesis of schizencephaly is therefore suggested.
ISSN:0364-5134
1531-8249
DOI:10.1002/ana.410430122