Forced limb-use enhanced neurogenesis and behavioral recovery after stroke in the aged rats

Highlights • Forced limb-use enhanced neurogenesis in the aged rats. • Forced limb-use suppressed apoptosis in the aged rats. • Forced limb-use is effective in behavioral recovery after stroke in the aged rats.

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Bibliographic Details
Published inNeuroscience Vol. 286; pp. 316 - 324
Main Authors Qu, H.L, Zhao, M, Zhao, S.S, Xiao, T, Song, C.G, Cao, Y.P, Jolkkonen, J, Zhao, C.S
Format Journal Article
LanguageEnglish
Published United States Elsevier Ltd 12.02.2015
Subjects
aging
Animals
Apoptosis
behavioral recovery
Brain Ischemia - chemically induced
Brain Ischemia - pathology
Brain Ischemia - rehabilitation
Cell Proliferation
Disease Models, Animal
Endothelin-1
forced limb-use
Lateral Ventricles - pathology
Lateral Ventricles - physiopathology
Locomotion
Male
Neurogenesis
Neurology
Neurons - physiology
Physical Therapy Modalities
Rats
Rats, Sprague-Dawley
Restraint, Physical
stroke
Stroke - chemically induced
Stroke - pathology
Stroke Rehabilitation
doublecortin
DG
SGZ
5-bromo-2-deoxyuridine
neuronal nuclei
CIMT
TUNEL
SVZ
neurogenesis
high-power field
endothelin-1
subventricular zone
subgranular zone
stroke
constraint-induced movement therapy
GFAP
forced limb-use
dentate gyrus
ET-1
NeuN
DCX
TdT-mediated dUTP-biotin nick-end labeling
aging
behavioral recovery
glial fibrillary acidic protein
BrdU
HPF
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Summary:Highlights • Forced limb-use enhanced neurogenesis in the aged rats. • Forced limb-use suppressed apoptosis in the aged rats. • Forced limb-use is effective in behavioral recovery after stroke in the aged rats.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2014.11.040