Behaviour and prefrontal protein differences in C57BL/6N and 129 X1/SvJ mice

Highlights • Relative to 129X1/SvJ, both sexes of C57BL/6N mice had weaker sensorimotor gating. • C57BL/6N mice were more sensitive to amphetamine challenge in the open field. • The protein expression in prefrontal cortex of C57BL/6N was distinct from 129X1/SvJ.

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Bibliographic Details
Published inBrain research bulletin Vol. 116; pp. 16 - 24
Main Authors Zhang, Xiaofan, Li, Qi, Wong, Naikei, Zhang, Min, Wang, Wei, Bu, Bitao, McAlonan, Grainne Mary
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.07.2015
Subjects
129X1/SvJ
Amphetamine - pharmacology
Amphetamine test
Animals
Blotting, Western
C57BL/6N
Central Nervous System Stimulants - pharmacology
Electrophoresis, Gel, Two-Dimensional
Female
Male
Mice, 129 Strain - physiology
Mice, Inbred C57BL - physiology
Motor Activity - drug effects
Motor Activity - physiology
Multivariate Analysis
Neurology
Prefrontal Cortex - metabolism
Prepulse inhibition
Proteomics
Reflex, Startle
Sensory Gating - physiology
Sex Characteristics
Species Specificity
pyruvate dehydrogenase
astrocyte glutamate transporter
C57BL/6N
ornithine aminotransferase
medial prefrontal cortex
OAT
129X1/SvJ
partial least squares-discriminant analysis
PPI
PKC
PLS-DA
prepulse inhibition
SOD2
GLAST
mPFC
Amphetamine test
PDH
superoxide dismutase
Proteomics
glyceraldehyde-3-phosphate dehydrogenase
GAPDH
protein kinase C
Prepulse inhibition
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Summary:Highlights • Relative to 129X1/SvJ, both sexes of C57BL/6N mice had weaker sensorimotor gating. • C57BL/6N mice were more sensitive to amphetamine challenge in the open field. • The protein expression in prefrontal cortex of C57BL/6N was distinct from 129X1/SvJ.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0361-9230
1873-2747
DOI:10.1016/j.brainresbull.2015.05.003