Antifungal active ingredient from the twigs and leaves of Clausena lansium Lour. Skeels (Rutaceae)
Two novel amides, named clauphenamides A and B, and twelve other known compounds were isolated from the twigs and leaves of Lour. Skeels (Rutaceae). Their structures were elucidated on the basis of extensive spectroscopic analysis and comparison with data reported in the literature. Clauphenamide A...
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| Published in | Frontiers in chemistry Vol. 10; p. 1104805 |
|---|---|
| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Switzerland
Frontiers Media S.A
13.12.2022
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| Subjects | |
| Online Access | Get full text |
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| Summary: | Two novel amides, named clauphenamides A and B, and twelve other known compounds were isolated from the twigs and leaves of
Lour. Skeels (Rutaceae). Their structures were elucidated on the basis of extensive spectroscopic analysis and comparison with data reported in the literature. Clauphenamide A (
) featured in the unit of N-2-(4,8-dimethoxyfuro [2,3-b]quinolin-7-yl)vinyl, and clauphenamide B (
) was a unprecedented N-phenethyl cinnamide dimer. Other known compounds belong to pyrrolidone amides (
and
), furacoumarins (
-
), simple coumarins (
-
), lignan (
) and sesquiterpene (
). Compounds
,
,
and
were separated from the genus (
) for the first time, while
was isolated in the species (
) for the first time. The antifungal activities of the isolated compounds were assayed. As a result, at the concentration of 100
g/ml, compared with the control (chlorothalonil, inhibition rate of 83.67%), compounds
and
were found to exhibit moderate antifungal activity against
with inhibition rates of 68.39% and 52.05%, respectively. Compounds
-
also exhibited moderate activity against
and
, with inhibition rates greater than 40%. In addition, compared with the control (chlorothalonil, inhibition rate of 69.02%), compounds
-
showed strong antifungal activity to
, with inhibition rates greater than 55%. Among them, compound
has the strongest antifungal activity against
, and the inhibition rate (65.44%) is close to that of the control chlorothalonil. Additionally, the structure-activity relationships of the separated compounds are also discussed preliminarily in this paper. |
|---|---|
| Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Chen Huabao, Sichuan Agricultural University, China Edited by: Yefeng Tang, Tsinghua University, China These authors have contributed equally to this work Ya Li, Lanzhou University, China This article was submitted to Organic Chemistry, a section of the journal Frontiers in Chemistry Reviewed by: Jiwen Zhang, Northwest A&F University, China |
| ISSN: | 2296-2646 2296-2646 |
| DOI: | 10.3389/fchem.2022.1104805 |