Structure of the Liver in Mice with Transplanted Lewis Carcinoma during Polychemotherapy and Correction with Betulonic Acid and Its Derivatives

Morphological and morphometric studies of the liver with transplanted Lewis carcinoma were performed after polychemotherapy and correction with betulonic and [3-oxo-20(29)-lupene- 28-oil]-3-aminopropionic acids and their methyl esters. It was demonstrated than betulonic and [3-oxo-20(29)-lupene-28-o...

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Published inBulletin of experimental biology and medicine Vol. 150; no. 1; pp. 96 - 99
Main Authors Zhukova, N. A., Sorokina, I. V., Tolstikova, T. G., Lushnikova, E. L., Nepomnyashih, L. M., Semenov, D. E.
Format Journal Article
LanguageEnglish
Published Boston Springer US 01.12.2010
Springer
Springer Nature B.V
Subjects
Animals
Antineoplastic Agents - chemistry
Antineoplastic Agents - therapeutic use
Biomedical and Life Sciences
Biomedicine
Cancer
Carcinoma
Carcinoma, Lewis Lung
Cell Biology
Drug Therapy, Combination - methods
Esters
Hepatocytes - drug effects
Hepatocytes - pathology
Internal Medicine
Laboratory Medicine
Liver
Liver - drug effects
Liver - pathology
Liver diseases
Liver Neoplasms - drug therapy
Mice
Mice, Inbred C57BL
Neoplasm Transplantation
Oleanolic Acid - analogs & derivatives
Oleanolic Acid - chemistry
Oleanolic Acid - therapeutic use
Pathology
Propionates - chemistry
Propionates - therapeutic use
Transplantation
liver monphology
lung carcinoma
hepatotoxicity
polychemotherapy
betulonic acid and their derivatives
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Summary:Morphological and morphometric studies of the liver with transplanted Lewis carcinoma were performed after polychemotherapy and correction with betulonic and [3-oxo-20(29)-lupene- 28-oil]-3-aminopropionic acids and their methyl esters. It was demonstrated than betulonic and [3-oxo-20(29)-lupene-28-oil]-3-aminopropionic acids reduced the degree of degenerative changes and volume density of necrotic changes in hepatocytes after polychemotherapy. Methyl esters of these acids little changed the severity and spreading of destructive and necrotic changes in the liver caused by complex cytostatic therapy. It was also shown that all studied triterpenoids exhibited more pronounced antimetastatic effect (evaluated by the decrease in volume density of liver metastases) compared to polychemotherapy.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-010-1079-9