Central amygdala nicotinic and 5-HT1A receptors mediate the reversal effect of nicotine and MDMA on morphine-induced amnesia

• Published in: Neuroscience Vol. 277; pp. 392 - 402
• Main Authors: Tirgar, F, Rezayof, A, Zarrindast, M.-R
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 26.09.2014
• Subjects: Amnesia - chemically induced; Amnesia - drug therapy; Amnesia - physiopathology; Animals; Central Amygdaloid Nucleus - drug effects; Central Amygdaloid Nucleus - physiopathology; cholinergic and serotonergic systems; Dose-Response Relationship, Drug; drugs of abuse; Male; Mecamylamine - pharmacology; memory retrieval; Morphine - pharmacology; N-Methyl-3,4-methylenedioxyamphetamine - pharmacology; Narcotics - pharmacology; Neurology; Nicotine - pharmacology; Nicotinic Agonists - pharmacology; Nicotinic Antagonists - pharmacology; Piperazines - pharmacology; rat(s); Rats, Wistar; Receptor, Serotonin, 5-HT1A - metabolism; Receptors, Nicotinic - metabolism; Serotonin 5-HT1 Receptor Antagonists - pharmacology; Serotonin Agents - pharmacology; 5-hydroxytryptamine 1A; CPP; conditioned place preference; memory retrieval; MORs; nACh; nicotinic acetylcholine; rat(s); MDMA; nAChRs; drugs of abuse; analysis of variance; ANOVA; central amygdala; 3,4-methylenedioxy- N-methylamphetamine; μ-opioid receptors; 5-HT1A; nicotinic acetylcholine receptors; CeA; cholinergic and serotonergic systems
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/j.neuroscience.2014.07.014

Highlights • Post-training administration of morphine impairs memory retrieval. • Pre-test administration of nicotine reversed morphine-induced amnesia. • Intra-CeA injection of MDMA potentiated nicotine response. • Intra-CeA injection of mecamylamine inhibited potentiative effect of MDMA. • Blockade of the CeA 5-HT1A receptors inhibited potentiative effect of MDMA.