The frequency of spontaneous seizures in rats correlates with alterations in sensorimotor gating, spatial working memory, and parvalbumin expression throughout limbic regions

• Published in: Neuroscience Vol. 312; pp. 86 - 98
• Main Authors: Wolf, D.C, Bueno-Júnior, L.S, Lopes-Aguiar, C, Do Val Da Silva, R.A, Kandratavicius, L, Leite, J.P
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 15.01.2016
• Subjects: Animals; Behavior, Animal - physiology; Disease Models, Animal; Epilepsy, Temporal Lobe - chemically induced; Epilepsy, Temporal Lobe - metabolism; Epilepsy, Temporal Lobe - physiopathology; Limbic System - metabolism; Limbic System - physiopathology; Lithium - pharmacology; lithium–pilocarpine; Male; Memory, Short-Term - physiology; Muscarinic Agonists - pharmacology; Neurology; parvalbumin immunohistochemistry; Parvalbumins - metabolism; Pilocarpine - pharmacology; Prefrontal Cortex - physiopathology; prepulse inhibition; psychiatric comorbidities; radial maze; Rats; Rats, Wistar; Seizures - chemically induced; Seizures - metabolism; Seizures - physiopathology; Sensory Gating - physiology; Spatial Memory - physiology; temporal lobe epilepsy; prelimbic area of the prefrontal cortex; PP; psychiatric comorbidities; PV; entorhinal cortex; control group; integrated optical density; granular layer of the dentate gyrus; NAc; TRN; MLT; Ammon’s horn of the hippocampus; PILO; Non-SE; EC; temporal lobe epilepsy; IL; prepulse inhibition of the acoustic startle; Ctrl; nucleus accumbens; prepulse inhibition; prepulse alone trial; lithium–pilocarpine; midline thalamus; rats that failed to express status epilepticus; thalamic reticular nucleus; RM; LiCl; infralimbic area of the prefrontal cortex; startling pulse alone trial; PPI; TLE; SE; eight-arm radial maze; analysis of variance; ANOVA; SRS; SP; CA; IOD; PP + SP; radial maze; lithium chloride; GL; pilocarpine hydrochloride; spontaneous recurrent seizures; parvalbumin immunohistochemistry; prepulse then startling pulse trial; status epilepticus; parvalbumin; PL; PP+SP
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/j.neuroscience.2015.11.008

Highlights • Cognitive and sensorimotor symptoms are correlated with seizure frequency. • Dysfunctions in prefrontal-associated circuits might explain interictal disorders. • Lithium–pilocarpine model reproduces comorbidities of temporal lobe epilepsy.