Active and Passive Smoking and Lifestyle Determinants of 8-Oxo-7,8-Dihydro-2′-Deoxyguanosine Levels in Human Leukocyte DNA

We investigated the effects of smoking and exposure to environmental tobacco smoke (ETS) on oxidative DNA damage by measuring 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodGuo) levels in DNA of leukocytes of healthy donors (30 smokers, 29 nonsmokers, and 28 ETS-exposed subjects). Nonsmokers had lower 8...

Full description

Saved in:
Bibliographic Details
Published inCancer epidemiology, biomarkers & prevention Vol. 14; no. 12; pp. 2975 - 2977
Main Authors LODOVICI, Maura, CALDINI, Silvia, LUCERI, Cristina, BAMBI, Franco, BODDI, Vieri, DOLARA, Piero
Format Journal Article
LanguageEnglish
Published Philadelphia, PA American Association for Cancer Research 01.12.2005
Subjects
Adolescent
Adult
Analysis of Variance
Biological and medical sciences
Coffee
Deoxyguanosine - analogs & derivatives
Deoxyguanosine - metabolism
DNA Damage
Humans
Italy
Leukocytes - chemistry
Life Style
Male
Medical sciences
Middle Aged
Regression Analysis
Smoking - blood
Tea
Tobacco Smoke Pollution
Tobacco, tobacco smoking
Toxicology
Tumors
Italy
Human
Cancerology
Deoxyguanosine
Leukocyte
DNA
Passive smoking
Genetics
Oxidation
Public health
Life style
Online AccessGet full text

Cover

Abstract We investigated the effects of smoking and exposure to environmental tobacco smoke (ETS) on oxidative DNA damage by measuring 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodGuo) levels in DNA of leukocytes of healthy donors (30 smokers, 29 nonsmokers, and 28 ETS-exposed subjects). Nonsmokers had lower 8-oxodGuo levels compared with smokers (5.94 ± 0.87 × 10 −6 and 19.85 ± 4.75 × 10 −6 2-deoxyguanosine, respectively, means ± SE, P = 0.00007). Subjects exposed to ETS had higher mean value of 8-oxodGuo compared with nonsmokers (9.18 ± 1.53 × 10 −6 2-deoxyguanosine, mean ± SE), nonsignificant by univariate analysis ( P = 0.074). Multiregression analysis indicated that the increase of 8-oxodGuo levels induced by ETS was significant ( P = 0.045) and that coffee and tea consumption reduced DNA oxidation ( P = 0.0053). Oxidative leukocyte DNA damage was positively correlated with plasma cotinine levels in ETS-exposed subjects ( r = 0.47, P < 0.01, n = 28) and was increased by age in nonsmokers and ETS-exposed subjects ( P = 0.049). The results seem to confirm that ETS exposure is capable of inducing some oxidative DNA damage in circulating leukocytes and that coffee and tea consumption might partially protect against smoking-induced oxidation damage. (Cancer Epidemiol Biomarkers Prev 2005;14(12):2975–7)
AbstractList Abstract We investigated the effects of smoking and exposure to environmental tobacco smoke (ETS) on oxidative DNA damage by measuring 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodGuo) levels in DNA of leukocytes of healthy donors (30 smokers, 29 nonsmokers, and 28 ETS-exposed subjects). Nonsmokers had lower 8-oxodGuo levels compared with smokers (5.94 ± 0.87 × 10−6 and 19.85 ± 4.75 × 10−6 2-deoxyguanosine, respectively, means ± SE, P = 0.00007). Subjects exposed to ETS had higher mean value of 8-oxodGuo compared with nonsmokers (9.18 ± 1.53 × 10−6 2-deoxyguanosine, mean ± SE), nonsignificant by univariate analysis (P = 0.074). Multiregression analysis indicated that the increase of 8-oxodGuo levels induced by ETS was significant (P = 0.045) and that coffee and tea consumption reduced DNA oxidation (P = 0.0053). Oxidative leukocyte DNA damage was positively correlated with plasma cotinine levels in ETS-exposed subjects (r = 0.47, P < 0.01, n = 28) and was increased by age in nonsmokers and ETS-exposed subjects (P = 0.049). The results seem to confirm that ETS exposure is capable of inducing some oxidative DNA damage in circulating leukocytes and that coffee and tea consumption might partially protect against smoking-induced oxidation damage. (Cancer Epidemiol Biomarkers Prev 2005;14(12):2975–7)
We investigated the effects of smoking and exposure to environmental tobacco smoke (ETS) on oxidative DNA damage by measuring 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodGuo) levels in DNA of leukocytes of healthy donors (30 smokers, 29 nonsmokers, and 28 ETS-exposed subjects). Nonsmokers had lower 8-oxodGuo levels compared with smokers (5.94 ± 0.87 × 10 −6 and 19.85 ± 4.75 × 10 −6 2-deoxyguanosine, respectively, means ± SE, P = 0.00007). Subjects exposed to ETS had higher mean value of 8-oxodGuo compared with nonsmokers (9.18 ± 1.53 × 10 −6 2-deoxyguanosine, mean ± SE), nonsignificant by univariate analysis ( P = 0.074). Multiregression analysis indicated that the increase of 8-oxodGuo levels induced by ETS was significant ( P = 0.045) and that coffee and tea consumption reduced DNA oxidation ( P = 0.0053). Oxidative leukocyte DNA damage was positively correlated with plasma cotinine levels in ETS-exposed subjects ( r = 0.47, P < 0.01, n = 28) and was increased by age in nonsmokers and ETS-exposed subjects ( P = 0.049). The results seem to confirm that ETS exposure is capable of inducing some oxidative DNA damage in circulating leukocytes and that coffee and tea consumption might partially protect against smoking-induced oxidation damage. (Cancer Epidemiol Biomarkers Prev 2005;14(12):2975–7)
We investigated the effects of smoking and exposure to environmental tobacco smoke (ETS) on oxidative DNA damage by measuring 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodGuo) levels in DNA of leukocytes of healthy donors (30 smokers, 29 nonsmokers, and 28 ETS-exposed subjects). Nonsmokers had lower 8-oxodGuo levels compared with smokers (5.94 +/- 0.87 x 10(-6) and 19.85 +/- 4.75 x 10(-6) 2-deoxyguanosine, respectively, means +/- SE, P = 0.00007). Subjects exposed to ETS had higher mean value of 8-oxodGuo compared with nonsmokers (9.18 +/- 1.53 x 10(-6) 2-deoxyguanosine, mean +/- SE), nonsignificant by univariate analysis (P = 0.074). Multiregression analysis indicated that the increase of 8-oxodGuo levels induced by ETS was significant (P = 0.045) and that coffee and tea consumption reduced DNA oxidation (P = 0.0053). Oxidative leukocyte DNA damage was positively correlated with plasma cotinine levels in ETS-exposed subjects (r = 0.47, P < 0.01, n = 28) and was increased by age in nonsmokers and ETS-exposed subjects (P = 0.049). The results seem to confirm that ETS exposure is capable of inducing some oxidative DNA damage in circulating leukocytes and that coffee and tea consumption might partially protect against smoking-induced oxidation damage.
We investigated the effects of smoking and exposure to environmental tobacco smoke (ETS) on oxidative DNA damage by measuring 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodGuo) levels in DNA of leukocytes of healthy donors (30 smokers, 29 nonsmokers, and 28 ETS-exposed subjects). Nonsmokers had lower 8-oxodGuo levels compared with smokers (5.94 plus or minus 0.87 x 10 super(-6) and 19.85 plus or minus 4.75 x 10 super(-6) 2-deoxyguanosine, respectively, means plus or minus SE, P = 0.00007). Subjects exposed to ETS had higher mean value of 8-oxodGuo compared with nonsmokers (9.18 plus or minus 1.53 x 10 super(-6) 2-deoxyguanosine, mean plus or minus SE), nonsignificant by univariate analysis (P = 0.074). Multiregression analysis indicated that the increase of 8-oxodGuo levels induced by ETS was significant (P = 0.045) and that coffee and tea consumption reduced DNA oxidation (P = 0.0053). Oxidative leukocyte DNA damage was positively correlated with plasma cotinine levels in ETS-exposed subjects (r = 0.47, P < 0.01, n = 28) and was increased by age in nonsmokers and ETS-exposed subjects (P = 0.049). The results seem to confirm that ETS exposure is capable of inducing some oxidative DNA damage in circulating leukocytes and that coffee and tea consumption might partially protect against smoking-induced oxidation damage. (Cancer Epidemiol Biomarkers Prev 2005; 14(12):2975-7)
Author Piero Dolara
Franco Bambi
Silvia Caldini
Maura Lodovici
Cristina Luceri
Vieri Boddi
Author_xml – sequence: 1
  givenname: Maura
  surname: LODOVICI
  fullname: LODOVICI, Maura
  organization: Department of Pharmacology, University of Florence, Italy
– sequence: 2
  givenname: Silvia
  surname: CALDINI
  fullname: CALDINI, Silvia
  organization: Department of Pharmacology, University of Florence, Italy
– sequence: 3
  givenname: Cristina
  surname: LUCERI
  fullname: LUCERI, Cristina
  organization: Department of Pharmacology, University of Florence, Italy
– sequence: 4
  givenname: Franco
  surname: BAMBI
  fullname: BAMBI, Franco
  organization: Blood Transfusion Unit, Mayer Hospital, Florence, Italy
– sequence: 5
  givenname: Vieri
  surname: BODDI
  fullname: BODDI, Vieri
  organization: Department of Public Health, University of Florence, Italy
– sequence: 6
  givenname: Piero
  surname: DOLARA
  fullname: DOLARA, Piero
  organization: Department of Pharmacology, University of Florence, Italy
BackLink http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17371105$$DView record in Pascal Francis
https://www.ncbi.nlm.nih.gov/pubmed/16365019$$D View this record in MEDLINE/PubMed
BookMark eNpFkNtu1DAQhi1URA_wCKDcgISEix3Hh1yuui2ttKKVgGvLm4x3TRO72ElppF7wTDwST4LDLuqVx6Nv_tF8x-jABw8IvabklFKuPlLCOa5rwU_Pb64wqTCpiXiGjihnCkvJ-UGu_zOH6Dil74QQWXP-Ah1SwQQntD5Cj4tmcPdQGN8WNyaluf7Sh1vnN_96K2chDVMHxRIGiL3zxg-pCLZQ-PohYPlB4aXbTm0MuPzz6zdeQniYNqPxITkPxQruoUuF88Xl2Buf_-NtaKYh531evETPrekSvNq_J-jbxfnXs0u8uv50dbZY4aYSasDAhAFREaVMSctKrSUTtuXW8LZk7RqAWAGmNNQqpXjbCstLCVWlqGWCScZO0Ltd7l0MP8Z8j-5daqDrjIcwJk1lVUpR8wzyHdjEkFIEq--i602cNCV61q5npXpWqrN2TSo9a89zb_YLxnUP7dPU3nMG3u4BkxrT2Wh849ITJ5mkOTpz73fc1m22P10E3WQSYoQEJjZbTStNS13WkrO_WTeb1g
CitedBy_id crossref_primary_10_1158_1078_0432_CCR_06_1460
crossref_primary_10_1016_j_yrtph_2018_02_002
crossref_primary_10_1007_s11357_015_9762_4
crossref_primary_10_3390_ijerph19159110
crossref_primary_10_1007_s00592_009_0149_9
crossref_primary_10_1186_s41935_019_0135_5
crossref_primary_10_1200_JCO_2009_24_5480
crossref_primary_10_3164_jcbn_22_144
crossref_primary_10_1002_em_20439
crossref_primary_10_1038_s41598_023_41190_6
crossref_primary_10_1016_j_endmts_2021_100091
crossref_primary_10_1158_1055_9965_EPI_05_0664
crossref_primary_10_3123_jemsge_31_43
crossref_primary_10_1080_09603123_2011_643230
crossref_primary_10_1155_2019_5953685
crossref_primary_10_3389_fendo_2017_00048
crossref_primary_10_3109_1354750X_2013_777116
crossref_primary_10_1016_j_mrrev_2021_108365
crossref_primary_10_1186_1617_9625_9_5
crossref_primary_10_1016_j_envint_2018_08_006
crossref_primary_10_3390_diagnostics10040239
crossref_primary_10_1016_j_clinbiochem_2009_02_022
crossref_primary_10_3390_ijerph6030874
crossref_primary_10_1016_j_mrfmmm_2007_09_002
crossref_primary_10_1016_j_lungcan_2007_11_013
Cites_doi 10.1016/S0140-6736(96)90013-6
10.1093/jnci/91.14.1194
10.1016/S0891-5849(03)00041-8
10.1093/carcin/18.4.825
10.1002/ijc.2910580613
10.3181/00379727-220-44375
10.1007/BF00543327
10.1038/349431a0
10.1093/clinchem/37.11.1989
10.1016/S1383-5718(98)00192-2
10.1006/enrs.1994.1059
10.1016/0959-8049(96)00031-7
10.1021/jf035208t
10.1158/1055-9965.1342.13.8
10.1016/S0304-3835(99)00424-3
10.1016/S0891-5849(99)00194-X
10.1111/j.1349-7006.2001.tb01041.x
10.1016/0891-5849(94)00209-3
10.1016/j.freeradbiomed.2003.07.002
10.1289/ehp.94102s105
10.1016/S0731-7085(00)00339-3
ContentType Journal Article
Copyright 2006 INIST-CNRS
Copyright_xml – notice: 2006 INIST-CNRS
DBID IQODW
CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
7TM
7U7
C1K
DOI 10.1158/1055-9965.EPI-04-0906
DatabaseName Pascal-Francis
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
Nucleic Acids Abstracts
Toxicology Abstracts
Environmental Sciences and Pollution Management
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
Toxicology Abstracts
Nucleic Acids Abstracts
Environmental Sciences and Pollution Management
DatabaseTitleList CrossRef

MEDLINE
Toxicology Abstracts
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
EISSN 1538-7755
EndPage 2977
ExternalDocumentID 10_1158_1055_9965_EPI_04_0906
16365019
17371105
14_12_2975
Genre Research Support, Non-U.S. Gov't
Journal Article
GeographicLocations Italy
GeographicLocations_xml – name: Italy
GroupedDBID -
08R
29B
2WC
34G
39C
3O-
53G
55
5GY
5VS
ABOCM
ACJLH
ACPRK
ADACO
ADBBV
ADBIT
AENEX
AFRAH
ALMA_UNASSIGNED_HOLDINGS
C1A
CS3
DIK
DU5
E3Z
EBS
EJD
F5P
FH7
FRP
H13
H~9
IH2
KQ8
L7B
OK1
P2P
PQEST
PQQKQ
RCR
RHF
RHI
SJN
UDS
VH1
WOQ
X7M
ZA5
ZXP
---
.55
18M
2FS
6J9
AAUGY
ADCOW
AFHIN
AI.
BR6
BTFSW
IQODW
QTD
W8F
WHG
AAJMC
CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
7TM
7U7
C1K
ID FETCH-LOGICAL-c468t-e36ae64088a21248b736fd5fa5d23dbee0f6ea2a1f8885dd6f527e4481f363733
ISSN 1055-9965
IngestDate Sun Sep 29 07:18:41 EDT 2024
Fri Aug 23 03:22:03 EDT 2024
Sat Sep 28 07:49:56 EDT 2024
Sun Oct 22 16:06:28 EDT 2023
Fri Jan 15 19:22:24 EST 2021
IsPeerReviewed true
IsScholarly true
Issue 12
Keywords Human
Cancerology
Deoxyguanosine
Leukocyte
DNA
Passive smoking
Genetics
Oxidation
Public health
Life style
Language English
License CC BY 4.0
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-c468t-e36ae64088a21248b736fd5fa5d23dbee0f6ea2a1f8885dd6f527e4481f363733
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
PMID 16365019
PQID 17427695
PQPubID 23462
PageCount 3
ParticipantIDs proquest_miscellaneous_17427695
crossref_primary_10_1158_1055_9965_EPI_04_0906
pubmed_primary_16365019
pascalfrancis_primary_17371105
highwire_cancerresearch_14_12_2975
ProviderPackageCode RHF
RHI
PublicationCentury 2000
PublicationDate 2005-12-01
PublicationDateYYYYMMDD 2005-12-01
PublicationDate_xml – month: 12
  year: 2005
  text: 2005-12-01
  day: 01
PublicationDecade 2000
PublicationPlace Philadelphia, PA
PublicationPlace_xml – name: Philadelphia, PA
– name: United States
PublicationTitle Cancer epidemiology, biomarkers & prevention
PublicationTitleAlternate Cancer Epidemiol Biomarkers Prev
PublicationYear 2005
Publisher American Association for Cancer Research
Publisher_xml – name: American Association for Cancer Research
References 2022061001412919700_BIB4
2022061001412919700_BIB3
2022061001412919700_BIB6
2022061001412919700_BIB5
2022061001412919700_BIB8
2022061001412919700_BIB7
2022061001412919700_BIB9
2022061001412919700_BIB2
2022061001412919700_BIB1
2022061001412919700_BIB20
2022061001412919700_BIB21
2022061001412919700_BIB22
2022061001412919700_BIB23
2022061001412919700_BIB24
2022061001412919700_BIB25
2022061001412919700_BIB16
2022061001412919700_BIB17
2022061001412919700_BIB18
2022061001412919700_BIB19
2022061001412919700_BIB10
2022061001412919700_BIB11
2022061001412919700_BIB12
2022061001412919700_BIB13
2022061001412919700_BIB14
2022061001412919700_BIB15
References_xml – ident: 2022061001412919700_BIB9
  doi: 10.1016/S0140-6736(96)90013-6
– ident: 2022061001412919700_BIB15
  doi: 10.1093/jnci/91.14.1194
– ident: 2022061001412919700_BIB21
  doi: 10.1016/S0891-5849(03)00041-8
– ident: 2022061001412919700_BIB6
  doi: 10.1093/carcin/18.4.825
– ident: 2022061001412919700_BIB7
  doi: 10.1002/ijc.2910580613
– ident: 2022061001412919700_BIB24
  doi: 10.3181/00379727-220-44375
– ident: 2022061001412919700_BIB17
  doi: 10.1007/BF00543327
– ident: 2022061001412919700_BIB3
  doi: 10.1038/349431a0
– ident: 2022061001412919700_BIB19
  doi: 10.1093/clinchem/37.11.1989
– ident: 2022061001412919700_BIB14
  doi: 10.1016/S1383-5718(98)00192-2
– ident: 2022061001412919700_BIB4
– ident: 2022061001412919700_BIB22
  doi: 10.1006/enrs.1994.1059
– ident: 2022061001412919700_BIB8
  doi: 10.1016/0959-8049(96)00031-7
– ident: 2022061001412919700_BIB12
– ident: 2022061001412919700_BIB25
  doi: 10.1021/jf035208t
– ident: 2022061001412919700_BIB23
  doi: 10.1158/1055-9965.1342.13.8
– ident: 2022061001412919700_BIB5
  doi: 10.1016/S0304-3835(99)00424-3
– ident: 2022061001412919700_BIB13
  doi: 10.1016/S0891-5849(99)00194-X
– ident: 2022061001412919700_BIB11
  doi: 10.1111/j.1349-7006.2001.tb01041.x
– ident: 2022061001412919700_BIB16
– ident: 2022061001412919700_BIB2
  doi: 10.1016/0891-5849(94)00209-3
– ident: 2022061001412919700_BIB10
  doi: 10.1016/j.freeradbiomed.2003.07.002
– ident: 2022061001412919700_BIB18
– ident: 2022061001412919700_BIB1
  doi: 10.1289/ehp.94102s105
– ident: 2022061001412919700_BIB20
  doi: 10.1016/S0731-7085(00)00339-3
SSID ssj0007955
Score 1.9818984
Snippet We investigated the effects of smoking and exposure to environmental tobacco smoke (ETS) on oxidative DNA damage by measuring...
Abstract We investigated the effects of smoking and exposure to environmental tobacco smoke (ETS) on oxidative DNA damage by measuring...
SourceID proquest
crossref
pubmed
pascalfrancis
highwire
SourceType Aggregation Database
Index Database
Publisher
StartPage 2975
SubjectTerms Adolescent
Adult
Analysis of Variance
Biological and medical sciences
Coffee
Deoxyguanosine - analogs & derivatives
Deoxyguanosine - metabolism
DNA Damage
Humans
Italy
Leukocytes - chemistry
Life Style
Male
Medical sciences
Middle Aged
Regression Analysis
Smoking - blood
Tea
Tobacco Smoke Pollution
Tobacco, tobacco smoking
Toxicology
Tumors
Title Active and Passive Smoking and Lifestyle Determinants of 8-Oxo-7,8-Dihydro-2′-Deoxyguanosine Levels in Human Leukocyte DNA
URI http://cebp.aacrjournals.org/content/14/12/2975.abstract
https://www.ncbi.nlm.nih.gov/pubmed/16365019
https://search.proquest.com/docview/17427695
Volume 14
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9NAEF6FIiEuiHfDo6wQt-IQe585hrSoQFpAbaXeLD_W1GprV0mMGsSB38T_4cIvYfbh2KkColwsZ-2MV57PszO738wi9EJRX6WSZl4sJQQoPqGelFHsBVlCffDoEsF1vvPuHt85pO-O2FGn87PFWqpmcS_5ujKv5H-0Cm2gV50lewXNLoRCA5yDfuEIGobjP-l4aIyVJfyDE6zP98_KkzrvcJxnYPPnp5oatEx6kd6Hi9IT8H6lt5Ufz9NJ6QWO9_A68LZUeTH_XEVFqVnxm2NNLDK8WTvlP1bVSZnMZyB3b9j2bkcaQpNN1ew6a1SoU_w1C2gyNUA7d1WjGgLAGGJjsFi5TR6qJg17KNJrY6Z9Pz_9ki8ujAGRNkd-ZKxU0cwrRGdxXrvkSbk0q8FaDBFriPuMeRCL2RVv1RhnIWxZ34X1pm2UBm1bPBCsNa7DT7F6zGDSTF-4B_a2P7411JxBf0WN7ktj54LRaGIpJkMtJtRiQhAT9mmoxVxD1wMxYJpx-v5TU8xeN5nFePdkl2AGYl6t7M2y61SXs9Zs3mgKH3Rmd2L5c6hkXKaD2-iWi3Xw0AL3Duqo4i66sevYHPfQN4tfDFjFDr_Y4de0LfCL2_jFZYYdfl-20Pvr-49LuMUWtzgvsMEtXuAWA27vo8M32wejHc_tBuIllMuZpwiPFKcwKkbgblEZC8KzlGURSwOSxkr1M66iIPIzKSVLU56xQChKpZ8RTgQhD9BaURZqHeHY5xnvBwlRIJDFiWR8wDiFSInFlCaki3r1iw7PbdGX8K8K7qLntTrCxHxqrlTXMYTWoR-EGotdtLGkqEa0IAK8cLjhWa25EIy8XrmLClVWU7iDBgL62EUPrUKb_3ICMZY_eHTVLj9GN5vv7glam00q9RT861m8YVD6GxZ1yVM
link.rule.ids 315,786,790,27955,27956
linkProvider Colorado Alliance of Research Libraries
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Active+and+Passive+Smoking+and+Lifestyle+Determinants+of+8-Oxo-7%2C8-Dihydro-2%E2%80%B2-Deoxyguanosine+Levels+in+Human+Leukocyte+DNA&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention&rft.au=Lodovici%2C+Maura&rft.au=Caldini%2C+Silvia&rft.au=Luceri%2C+Cristina&rft.au=Bambi%2C+Franco&rft.date=2005-12-01&rft.issn=1055-9965&rft.eissn=1538-7755&rft.volume=14&rft.issue=12&rft.spage=2975&rft.epage=2977&rft_id=info:doi/10.1158%2F1055-9965.EPI-04-0906&rft.externalDBID=n%2Fa&rft.externalDocID=10_1158_1055_9965_EPI_04_0906
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1055-9965&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1055-9965&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1055-9965&client=summon