An update on the therapeutic implications of long-chain acyl-coenzyme A synthetases in nervous system diseases

• Published in: Frontiers in neuroscience Vol. 16; p. 1030512
• Main Authors: Wu, Zhimin, Sun, Jun, Liao, Zhi, Qiao, Jia, Chen, Chuan, Ling, Cong, Wang, Hui
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 24.11.2022
• Subjects: fatty acid (FA) metabolism; ferroptosis; long-chain acyl-coenzyme A synthetases (ACSLs); nervous system diseases; Neuroscience; targeted therapy; long-chain acyl-coenzyme A synthetases (ACSLs); nervous system diseases; targeted therapy; fatty acid (FA) metabolism; ferroptosis

Long-chain acyl-coenzyme A synthetases (ACSLs) are a family of CoA synthetases that activate fatty acid (FA) with chain lengths of 12–20 carbon atoms by forming the acyl-AMP derivative in an isozyme-specific manner. This family mainly includes five members (ACSL1, ACSL3, ACSL4, ACSL5, and ACSL6), wh...