An update on the therapeutic implications of long-chain acyl-coenzyme A synthetases in nervous system diseases

Long-chain acyl-coenzyme A synthetases (ACSLs) are a family of CoA synthetases that activate fatty acid (FA) with chain lengths of 12–20 carbon atoms by forming the acyl-AMP derivative in an isozyme-specific manner. This family mainly includes five members (ACSL1, ACSL3, ACSL4, ACSL5, and ACSL6), wh...

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Published inFrontiers in neuroscience Vol. 16; p. 1030512
Main Authors Wu, Zhimin, Sun, Jun, Liao, Zhi, Qiao, Jia, Chen, Chuan, Ling, Cong, Wang, Hui
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 24.11.2022
Subjects
fatty acid (FA) metabolism
ferroptosis
long-chain acyl-coenzyme A synthetases (ACSLs)
nervous system diseases
Neuroscience
targeted therapy
long-chain acyl-coenzyme A synthetases (ACSLs)
nervous system diseases
targeted therapy
fatty acid (FA) metabolism
ferroptosis
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Summary:Long-chain acyl-coenzyme A synthetases (ACSLs) are a family of CoA synthetases that activate fatty acid (FA) with chain lengths of 12–20 carbon atoms by forming the acyl-AMP derivative in an isozyme-specific manner. This family mainly includes five members (ACSL1, ACSL3, ACSL4, ACSL5, and ACSL6), which are thought to have specific and different functions in FA metabolism and oxidative stress of mammals. Accumulating evidence shows that the dysfunction of ACSLs is likely to affect cell proliferation and lead to metabolic diseases in multiple organs and systems through different signaling pathways and molecular mechanisms. Hence, a central theme of this review is to emphasize the therapeutic implications of ACSLs in nervous system disorders.
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This article was submitted to Neuropharmacology, a section of the journal Frontiers in Neuroscience
Edited by: Zhengwu Peng, Fourth Military Medical University, China
Reviewed by: Jeroen Bogie, University of Hasselt, Belgium; Caterina Bartolacci, University of Cincinnati, United States
These authors have contributed equally to this work
ISSN:1662-453X
1662-4548
1662-453X
DOI:10.3389/fnins.2022.1030512